PMID- 25498415
OWN - NLM
STAT- MEDLINE
DCOM- 20150902
LR  - 20181202
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 25
IP  - 1
DP  - 2015 Jan
TI  - Cross-sex hormone treatment in male-to-female transsexual persons reduces serum 
      brain-derived neurotrophic factor (BDNF).
PG  - 95-9
LID - S0924-977X(14)00330-7 [pii]
LID - 10.1016/j.euroneuro.2014.11.019 [doi]
AB  - Serum levels of brain-derived neurotrophic factor (BDNF) are reduced in 
      male-to-female transsexual persons (MtF) compared to male controls. It was 
      hypothesized before that this might reflect either an involvement of BDNF in a 
      biomechanism of transsexualism or to be the result of persistent social stress 
      due to the condition. Here, we demonstrate that 12 month of cross-sex hormone 
      treatment reduces serum BDNF levels in male-to-female transsexual persons 
      independent of anthropometric measures. Participants were acquired through the 
      European Network for the Investigation of Gender Incongruence (ENIGI). Reduced 
      serum BDNF in MtF thus seems to be a result of hormonal treatment rather than a 
      consequence or risk factor of transsexualism.
CI  - Copyright (c) 2014 Elsevier B.V. and ECNP. All rights reserved.
FAU - Fuss, Johannes
AU  - Fuss J
AD  - Institute for Sex Research and Forensic Psychiatry, Center for Psychosocial 
      Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 
      Electronic address: jo.fuss@uke.de.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - Department of Psychiatry, University of Medicine of Berlin, Campus Charite Mitte, 
      Berlin, Germany.
FAU - Van Caenegem, Eva
AU  - Van Caenegem E
AD  - Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
FAU - Briken, Peer
AU  - Briken P
AD  - Institute for Sex Research and Forensic Psychiatry, Center for Psychosocial 
      Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Stalla, Gunter K
AU  - Stalla GK
AD  - Endocrinology, Diabetology and Internal Medicine, Max Planck Institute of 
      Psychiatry, Munich, Germany.
FAU - T'Sjoen, Guy
AU  - T'Sjoen G
AD  - Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
FAU - Auer, Matthias K
AU  - Auer MK
AD  - Endocrinology, Diabetology and Internal Medicine, Max Planck Institute of 
      Psychiatry, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20141204
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Contraceptive Agents)
RN  - 0 (Estrogens)
RN  - 4KM2BN5JHF (Cyproterone Acetate)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anthropometry/methods
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Contraceptive Agents/*therapeutic use
MH  - Cyproterone Acetate/therapeutic use
MH  - Estradiol/analogs & derivatives
MH  - Estrogens
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Retrospective Studies
MH  - *Transgender Persons
MH  - Transsexualism/*blood/*drug therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Estradiol
OT  - Gender dysphoria
OT  - Gender identity disorder
OT  - Neurotrophin
OT  - Testosterone
OT  - Transgender
EDAT- 2014/12/17 06:00
MHDA- 2015/09/04 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/09/04 00:00 [received]
PHST- 2014/11/17 00:00 [revised]
PHST- 2014/11/24 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - S0924-977X(14)00330-7 [pii]
AID - 10.1016/j.euroneuro.2014.11.019 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2015 Jan;25(1):95-9. doi: 
      10.1016/j.euroneuro.2014.11.019. Epub 2014 Dec 4.