PMID- 25498613
OWN - NLM
STAT- MEDLINE
DCOM- 20151012
LR  - 20220408
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 117
DP  - 2015 Mar 6
TI  - Hypoglycemic and hypolipidemic properties of polysaccharides from Enterobacter 
      cloacae Z0206 in KKAy mice.
PG  - 91-98
LID - S0144-8617(14)00885-6 [pii]
LID - 10.1016/j.carbpol.2014.09.008 [doi]
AB  - The water-soluble polysaccharides (EPS) were isolated from culture broth of 
      Enterobacter cloacae Z0206, and the hypoglycemic and hypolipidemic effects of EPS 
      were investigated. In this study, KKAy mice were gavaged once daily with either 
      distilled water or EPS (200 mg/kg body weight) for 6 weeks. Results showed that 
      EPS possessed significant hypoglycemic effects. Improved oral glucose tolerance, 
      reduced serum insulin levels as well as decreased serum triglycerides (TG), 
      cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) were observed 
      after treatment with EPS. Furthermore, EPS upregulated the expression of 
      glucokinase (GK), HSL (Hormone Sensitive Lipase), adipose triglyceride lipase 
      (ATGL), carnitine palmitoyl transferase 1-alpha (CPT1-alpha), glucose transporter 2 
      (Glut2), adenosine monophosphate activated protein kinase (AMPK) and silent 
      information regulator 1 (Sirt1), but downregulated the gene expression of 
      glucose-6-phosphatase (G6P) and fatty acid synthase (FAS) in the liver. These 
      results suggest that EPS exhibits hypoglycemic and hypolipidemic effects possibly 
      through regulating AMPK- and SirT1-mediated effects on carbohydrate and lipid 
      metabolism.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Huang, Ming
AU  - Huang M
AD  - The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College 
      of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 
      310058, PR China.
FAU - Wang, Fengqin
AU  - Wang F
AD  - The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College 
      of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 
      310058, PR China.
FAU - Zhou, Xihong
AU  - Zhou X
AD  - The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College 
      of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 
      310058, PR China.
FAU - Yang, Hangxian
AU  - Yang H
AD  - The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College 
      of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 
      310058, PR China.
FAU - Wang, Yizhen
AU  - Wang Y
AD  - The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College 
      of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 
      310058, PR China. Electronic address: yzwang@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140928
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Polysaccharides)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Enterobacter cloacae/*chemistry
MH  - Fasting/blood
MH  - Glucose Tolerance Test
MH  - Glycogen/metabolism
MH  - Hexokinase/metabolism
MH  - Hypoglycemic Agents/*pharmacology
MH  - Hypolipidemic Agents/*pharmacology
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Polysaccharides/*pharmacology
OTO - NOTNLM
OT  - Hypoglycemic
OT  - KKAy mice
OT  - Polysaccharide
OT  - Type 2 diabetes
EDAT- 2014/12/17 06:00
MHDA- 2015/10/13 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/01/07 00:00 [received]
PHST- 2014/08/11 00:00 [revised]
PHST- 2014/09/07 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/10/13 06:00 [medline]
AID - S0144-8617(14)00885-6 [pii]
AID - 10.1016/j.carbpol.2014.09.008 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2015 Mar 6;117:91-98. doi: 10.1016/j.carbpol.2014.09.008. Epub 
      2014 Sep 28.