PMID- 25499313
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20150119
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 286
DP  - 2015 Feb 12
TI  - Cross-generational trans fat intake facilitates mania-like behavior: oxidative 
      and molecular markers in brain cortex.
PG  - 353-63
LID - S0306-4522(14)01027-6 [pii]
LID - 10.1016/j.neuroscience.2014.11.059 [doi]
AB  - Since that fast food consumption have raised concerns about people's health, we 
      evaluated the influence of trans fat consumption on behavioral, biochemical and 
      molecular changes in the brain-cortex of second generation rats exposed to a 
      model of mania. Two successive generations of female rats were supplemented with 
      soybean oil (SO, rich in n-6 FA, control group), fish oil (FO, rich in n-3 FA) 
      and hydrogenated vegetable fat (HVF, rich in trans FA) from pregnancy, lactation 
      to adulthood, when male rats from 2nd generation received amphetamine (AMPH-4 
      mg/kg-i.p., once a day, for 14 days) treatment. AMPH increased locomotor index in 
      all animals, which was higher in the HVF group. While the FO group showed 
      increased n-3 polyunsaturated fatty acid (PUFA) incorporation and reduced n-6/n-3 
      PUFA ratio, HVF allowed trans fatty acid (TFA) incorporation and increased 
      n-6/n-3 PUFA ratio in the brain-cortex. In fact, the FO group showed minor 
      AMPH-induced hyperactivity, decreased reactive species (RS) generation per se, 
      causing no changes in protein carbonyl (PC) levels and dopamine transporter 
      (DAT). FO supplementation showed molecular changes, since proBDNF was increased 
      per se and reduced by AMPH, decreasing the brain-derived neurotrophic factor 
      (BDNF) level following drug treatment. Conversely, HVF was related to increased 
      hyperactivity, higher PC level per se and higher AMPH-induced PC level, 
      reflecting on DAT, whose levels were decreased per se as well as in AMPH-treated 
      groups. In addition, while HVF increased BDNF-mRNA per se, AMPH reduced this 
      value, acting on BDNF, whose level was lower in the same AMPH-treated 
      experimental group. ProBDNF level was influenced by HVF supplementation, but it 
      was not sufficient to modify BDNF level. These findings reinforce that prolonged 
      consumption of trans fat allows TFA incorporation in the cortex, facilitating 
      hyperactive behavior, oxidative damages and molecular changes. Our study is a 
      warning about cross-generational consumption of processed food, since high trans 
      fat may facilitate the development of neuropsychiatric conditions, including 
      bipolar disorder (BD).
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Trevizol, F
AU  - Trevizol F
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Roversi, Kr
AU  - Roversi K
AD  - Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil.
FAU - Dias, V T
AU  - Dias VT
AD  - Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil.
FAU - Roversi, K
AU  - Roversi K
AD  - Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil.
FAU - Barcelos, R C S
AU  - Barcelos RC
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Kuhn, F T
AU  - Kuhn FT
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Pase, C S
AU  - Pase CS
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Golombieski, R
AU  - Golombieski R
AD  - Departamento de Ciencias Naturais e Exatas, UFSM, RS, Brazil.
FAU - Veit, J C
AU  - Veit JC
AD  - Programa de Pos-Graduacao em Ciencia e Tecnologia dos Alimentos, UFSM, RS, 
      Brazil.
FAU - Piccolo, J
AU  - Piccolo J
AD  - Programa de Pos-Graduacao em Ciencia e Tecnologia dos Alimentos, UFSM, RS, 
      Brazil.
FAU - Pochmann, D
AU  - Pochmann D
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Universidade 
      federal do Rio grande do Sul (UFRGS), RS, Brazil.
FAU - Porciuncula, L O
AU  - Porciuncula LO
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Universidade 
      federal do Rio grande do Sul (UFRGS), RS, Brazil.
FAU - Emanuelli, T
AU  - Emanuelli T
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil; Programa de Pos-Graduacao em Ciencia e Tecnologia dos 
      Alimentos, UFSM, RS, Brazil.
FAU - Rocha, J B T
AU  - Rocha JB
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Burger, M E
AU  - Burger ME
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil; Programa de Pos-Graduacao em Bioquimica Toxicologica, UFSM, 
      RS, Brazil; Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil. 
      Electronic address: mariliseeb@yahoo.com.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141208
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Fish Oils)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Trans Fatty Acids)
RN  - 8001-22-7 (Soybean Oil)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Age Factors
MH  - Amphetamine
MH  - Animals
MH  - Bipolar Disorder/chemically induced/*metabolism/*psychology
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Fatty Acids, Omega-3/analysis
MH  - Fatty Acids, Omega-6/analysis
MH  - Female
MH  - Fish Oils
MH  - Male
MH  - Motor Activity
MH  - Pregnancy
MH  - Protein Carbonylation
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species
MH  - Soybean Oil
MH  - Trans Fatty Acids/analysis/*toxicity
OTO - NOTNLM
OT  - BDNF
OT  - DAT
OT  - animal model of mania
OT  - bipolar disorder
OT  - oxidative damage
OT  - trans fat
EDAT- 2014/12/17 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/08/18 00:00 [received]
PHST- 2014/11/15 00:00 [revised]
PHST- 2014/11/30 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0306-4522(14)01027-6 [pii]
AID - 10.1016/j.neuroscience.2014.11.059 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Feb 12;286:353-63. doi: 10.1016/j.neuroscience.2014.11.059. 
      Epub 2014 Dec 8.