PMID- 25499849
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20161125
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 79
DP  - 2015 Feb
TI  - Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin 
      cells.
PG  - 164-75
LID - S0891-5849(14)01400-2 [pii]
LID - 10.1016/j.freeradbiomed.2014.12.004 [doi]
AB  - Linoleates are required for normal mammalian health and development, but they are 
      also prone to oxidation, resulting in biologically active metabolites such as 
      hydroxyoctadecadienoic acids (HODEs). To investigate the biological activity of 
      9-EZ-HODE, 10-EZ-HODE, 12-ZE-HODE, and 13-ZE-HODE, the metabolites of 
      singlet-oxygen-derived products from linoleates, we assessed adaptive 
      cytoprotection in HaCaT skin cells. Treating HaCaT cells with sublethal 
      concentrations of 10-EZ-HODE and 12-ZE-HODE, which are singlet-oxygen-mediated 
      specific oxidation metabolites of linoleates, but not 9-EZ-HODE and 13-ZE-HODE, 
      caused resistance to hydrogen peroxide-induced oxidative damage. Microarray 
      analysis of HaCaT cells revealed that 10-EZ-HODE and 12-ZE-HODE induced cellular 
      antioxidant genes that are responsive to nuclear factor-erythroid 2 p45-related 
      factor 2 (Nrf2), such as heme oxygenase-1 and glutathione synthesis enzymes. 
      Although 10-EZ-HODE and 12-ZE-HODE did not induce Nrf2 mRNA, treatment with these 
      metabolites increased the intranuclear expression of Nrf2. These results suggest 
      that 10-EZ-HODE and 12-ZE-HODE initiate adaptive responses that reduce the damage 
      caused by oxidative stress.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Akazawa-Ogawa, Yoko
AU  - Akazawa-Ogawa Y
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan. Electronic address: yoko-ogawa@aist.go.jp.
FAU - Shichiri, Mototada
AU  - Shichiri M
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan.
FAU - Nishio, Keiko
AU  - Nishio K
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan.
FAU - Yoshida, Yasukazu
AU  - Yoshida Y
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan.
FAU - Niki, Etsuo
AU  - Niki E
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan.
FAU - Hagihara, Yoshihisa
AU  - Hagihara Y
AD  - National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 
      563-8577, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141211
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 17778-80-2 (Singlet Oxygen)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Cell Line
MH  - Chromatography, Liquid
MH  - Heme Oxygenase-1/metabolism
MH  - Humans
MH  - Linoleic Acid/*metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Oligonucleotide Array Sequence Analysis
MH  - Protein Transport
MH  - Proto-Oncogene Proteins c-jun/metabolism
MH  - *Signal Transduction
MH  - Singlet Oxygen/chemistry/*metabolism
MH  - Skin/cytology/*metabolism
MH  - Tandem Mass Spectrometry
MH  - Ultraviolet Rays
OTO - NOTNLM
OT  - Cell signaling
OT  - Fatty acid oxidation
OT  - Free radicals
OT  - Glutathione synthase
OT  - Lipid oxidation
OT  - Nrf2
OT  - Nuclear factor 2-erythroid 2 p45-related factor 2
EDAT- 2014/12/17 06:00
MHDA- 2016/01/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/07/19 00:00 [received]
PHST- 2014/11/19 00:00 [revised]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
AID - S0891-5849(14)01400-2 [pii]
AID - 10.1016/j.freeradbiomed.2014.12.004 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2015 Feb;79:164-75. doi: 
      10.1016/j.freeradbiomed.2014.12.004. Epub 2014 Dec 11.