PMID- 25500149
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20150223
IS  - 1096-0961 (Electronic)
IS  - 1079-9796 (Linking)
VI  - 54
IP  - 3
DP  - 2015 Mar
TI  - Monocyte chemoatractant protein-1: a potential biomarker of renal lesion and its 
      relation with oxidative status in sickle cell disease.
PG  - 297-301
LID - S1079-9796(14)00152-1 [pii]
LID - 10.1016/j.bcmd.2014.11.019 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the monocyte chemoatractant 
      protein-1 (MCP-1) as a novel biomarker of renal lesion in sickle cell disease 
      (SCD) and correlate it with oxidative stress. METHODS: This is a prospective 
      study with SCD patients followed at a tertiary center in Brazil. Urine samples 
      were collected to dosage of protein, MCP-1, malondialdehyde (MDA) and urinary 
      creatinine. Patients taking hydroxyurea (SSHU) were compared to those not taking 
      the drug (SS). Patients' data were also compared to a control group of 15 healthy 
      blood donors. RESULTS: MCP-1 dosage was increased in SCD patients (Control: 
      42.12+/-27.6; SSHU: 168.2+/-90.1 and SS: 231.4+/-123.7 p<0.0001). SS patients presented 
      higher levels of MCP-1 in comparison to SSHU group (SSHU: 168.2+/-90.10 and SS: 
      231.4+/-123.7; p=0.023). The same results were observed for MDA (Control: 
      2:29+/-1:13; SSHU: 5.60+/-2.39 and SS: 7.23+/-2.64, p<0.0001) and NO (control: 
      2.25+/-1.9; SSHU: 56.54+/-9.1 and SS: 39.1+/-9.02, p<0.0001). A positive correlation 
      was obtained between MCP-1 and MDA (r=0.34, p=0.01); albuminuria (r=0.5, p=0.03); 
      NO (r=0.39, p=0.005). CONCLUSION: The outcomes of the study suggest that MCP-1 is 
      a predictive biomarker of renal lesion that can also reflect damage caused by 
      oxidative stress present in SCD.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - dos Santos, Talyta Ellen de Jesus
AU  - dos Santos TE
AD  - Post-Graduation Program in Pharmaceutical Sciences, School of Pharmacy, Federal 
      University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      talytaellen08@hotmail.com.
FAU - Goncalves, Romelia Pinheiro
AU  - Goncalves RP
AD  - Post-Graduation Program in Pharmaceutical Sciences, School of Pharmacy, Federal 
      University of Ceara, Fortaleza, Ceara, Brazil.
FAU - Barbosa, Maritza Cavalcante
AU  - Barbosa MC
AD  - Post-Graduation Program in Pharmaceutical Sciences, School of Pharmacy, Federal 
      University of Ceara, Fortaleza, Ceara, Brazil.
FAU - da Silva, Geraldo Bezerra Jr
AU  - da Silva GB Jr
AD  - School of Medicine, Master in Collective Health, Health Sciences Center, 
      University of Fortaleza, Fortaleza, Ceara, Brazil. Electronic address: 
      geraldobezerrajr@yahoo.com.br.
FAU - Daher, Elizabeth De Francesco
AU  - Daher Ede F
AD  - Department of Internal Medicine, School of Medicine, Federal University of Ceara, 
      Fortaleza, Ceara, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20141126
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Albuminuria/etiology/metabolism
MH  - Anemia, Sickle Cell/*complications/epidemiology/metabolism/*urine
MH  - Brazil/epidemiology
MH  - Chemokine CCL2/*urine
MH  - Female
MH  - Humans
MH  - Kidney/metabolism/pathology
MH  - Kidney Diseases/*etiology/metabolism/urine
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Prospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Biomarker
OT  - Kidney diseases
OT  - Monocyte chemoatractant protein
OT  - Sickle cell disease
EDAT- 2014/12/17 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/09/25 00:00 [received]
PHST- 2014/11/15 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1079-9796(14)00152-1 [pii]
AID - 10.1016/j.bcmd.2014.11.019 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2015 Mar;54(3):297-301. doi: 10.1016/j.bcmd.2014.11.019. 
      Epub 2014 Nov 26.