PMID- 25500181
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20220311
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Feb
TI  - Clinical guidelines for IVF with PGD for HLA matching.
PG  - 115-9
LID - S1472-6483(14)00582-3 [pii]
LID - 10.1016/j.rbmo.2014.10.007 [doi]
AB  - Preimplantation genetic diagnosis (PGD) for human leukocyte antigen (HLA) typing 
      is an established procedure for conceiving a child who may donate cord blood or 
      haematopoietic stem cells for transplantation to save an ill sibling. 
      Haematopoietic stem cell transplantation (HSCT) from related matched donors 
      improves overall survival compared with unrelated or non-matched donors. Since 
      HSCT from related matched-donors is unavailable for 70% of patients, IVF for 
      PGD-HLA is a relevant clinical option. Recent success of HSCT after PGD-HLA, and 
      excellent health and family support of the children born, suggests that debate 
      over this kind of 'designer baby' and 'gift of life' should subside. Discussions 
      about IVF for PGD-HLA should be held with families when a related matched-donor 
      is unavailable, when HSCT can wait at least 9-12 months, within weeks of 
      diagnosis irrespective of prognosis, and when the mother is of reproductive age. 
      Related half-matched egg donors may also be considered. National and 
      international collaborations should be established, and couples choosing this 
      modality should be referred to experienced IVF and PGD centres. Clinical 
      guidelines will improve physician and patient awareness of IVF for PGD-HLA and 
      its role in advancing the clinical care of children in need of HSCT.
CI  - Copyright (c) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Tur-Kaspa, Ilan
AU  - Tur-Kaspa I
AD  - Institute for Human Reproduction (IHR), 409 West Huron Street, Suite 500, 
      Chicago, IL, United States; Department of Obstetrics and Gynecology, The 
      University of Chicago, 5841 S. Maryland Ave-MC2050, Chicago, IL, United States. 
      Electronic address: DrTK@infertilityIHR.com.
FAU - Jeelani, Roohi
AU  - Jeelani R
AD  - Institute for Human Reproduction (IHR), 409 West Huron Street, Suite 500, 
      Chicago, IL, United States; Department of Obstetrics and Gynecology, Wayne State 
      University/DMC, 3980 John St, Detroit, MI, United States.
LA  - eng
PT  - Journal Article
DEP - 20141018
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Fertilization in Vitro/*standards
MH  - Fetal Blood/cytology
MH  - HLA Antigens/*chemistry
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Patient Education as Topic
MH  - Preimplantation Diagnosis/*standards
MH  - Siblings
MH  - *Tissue Donors
OTO - NOTNLM
OT  - PGD
OT  - bone marrow transplant
OT  - cord blood
OT  - hematopoietic stem cell transplantation
OT  - human leukocyte antigen matching
OT  - inherited and acquired hematological disorders
EDAT- 2014/12/17 06:00
MHDA- 2016/01/12 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2014/09/27 00:00 [revised]
PHST- 2014/10/09 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
AID - S1472-6483(14)00582-3 [pii]
AID - 10.1016/j.rbmo.2014.10.007 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2015 Feb;30(2):115-9. doi: 10.1016/j.rbmo.2014.10.007. Epub 
      2014 Oct 18.