PMID- 25500443
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 53
IP  - 24
DP  - 2014
TI  - Rapid multiorgan failure due to large B-cell lymphoma arising in human 
      herpesvirus-8-associated multicentric Castleman's disease in a patient with human 
      immunodeficiency virus infection.
PG  - 2805-9
AB  - A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, 
      hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without 
      severe immunosuppression. We suspected human herpesvirus-8 (HHV-8)-associated 
      multicentric Castleman's disease (MCD) based on the results of a physical 
      examination and laboratory investigations, including bone marrow aspiration. 
      However, the patient died eight days after admission due to multiorgan failure. 
      An autopsy revealed MCD and lymphoma cell infiltration in multiple organs. The 
      final diagnosis was large B-cell lymphoma (LBCL) arising in HHV-8-associated MCD. 
      This case illustrates the potential for LBCL in HHV-8 MCD in HIV-infected 
      patients with hepatosplenomegaly and lymphadenopathy without severe 
      immunosuppression and highlights the clinical significance of bone marrow 
      aspiration.
FAU - Ogawa, Yoshihiko
AU  - Ogawa Y
AD  - Department of Infectious Diseases, National Hospital Organization Osaka National 
      Hospital, Japan.
FAU - Watanabe, Dai
AU  - Watanabe D
FAU - Hirota, Kazuyuki
AU  - Hirota K
FAU - Ikuma, Motoko
AU  - Ikuma M
FAU - Yajima, Keishiro
AU  - Yajima K
FAU - Kasai, Daisuke
AU  - Kasai D
FAU - Mori, Kiyoshi
AU  - Mori K
FAU - Ota, Yasunori
AU  - Ota Y
FAU - Nishida, Yasuharu
AU  - Nishida Y
FAU - Uehira, Tomoko
AU  - Uehira T
FAU - Mano, Masayuki
AU  - Mano M
FAU - Yamane, Takahisa
AU  - Yamane T
FAU - Shirasaka, Takuma
AU  - Shirasaka T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20141215
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - Multi-centric Castleman's Disease
SB  - IM
MH  - Bone Marrow/pathology
MH  - Castleman Disease/*complications/pathology/virology
MH  - Fatal Outcome
MH  - HIV Infections/*complications/pathology
MH  - Herpesvirus 8, Human/isolation & purification
MH  - Humans
MH  - Lymphoma, B-Cell/*complications/pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure/*etiology
EDAT- 2014/12/17 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/53.2212 [pii]
AID - 10.2169/internalmedicine.53.2212 [doi]
PST - ppublish
SO  - Intern Med. 2014;53(24):2805-9. doi: 10.2169/internalmedicine.53.2212. Epub 2014 
      Dec 15.