PMID- 25501804
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20220318
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 36
IP  - 5
DP  - 2015 May
TI  - BDNF plasma levels variations in major depressed patients receiving duloxetine.
PG  - 729-34
LID - 10.1007/s10072-014-2027-7 [doi]
AB  - It has been frequently reported that brain-derived neurotrophic factor (BDNF) 
      plays an important role in the pathophysiology of major depressive disorder 
      (MDD). Objective of the study was to investigate BDNF levels variations in MDD 
      patients during antidepressant treatment with duloxetine. 30 MDD patients and 32 
      healthy controls were assessed using Hamilton Depression Scale (HAM-D) and 
      monitored for BDNF plasma levels at baseline, week 6 and week 12 of duloxetine 
      treatment (60 mg/day) and at baseline, respectively. According to early clinical 
      response to duloxetine (defined at week 6 by reduction >50 % of baseline HAM-D 
      score), MDD patients were distinguished in early responders (ER) and early 
      non-responders (ENR), who reached clinical response at week 12. Laboratory 
      analysis showed significant lower baseline BDNF levels among patients compared to 
      controls. During duloxetine treatment, in ENR BDNF levels increased, reaching 
      values not significantly different compared to controls, while in ER BDNF levels 
      remained nearly unchanged. Lower baseline BDNF levels observed in patients 
      possibly confirm an impairment of the NEI stress-adaptation system and 
      neuroplasticity in depression, while BDNF increase and normalization observed 
      only in ENR might suggest differential neurobiological backgrounds in ER vs. ENR 
      within the depressive syndrome.
FAU - Fornaro, Michele
AU  - Fornaro M
AD  - Section of Psychiatry, Department of Neuroscience, IRCCS AOU San Martino-IST, 
      Ospedale San Martino, Largo Rosanna Benzi n.16, 16100, Genoa, Italy, 
      Dott.Fornaro@gmail.com.
FAU - Escelsior, Andrea
AU  - Escelsior A
FAU - Rocchi, Giulio
AU  - Rocchi G
FAU - Conio, Benedetta
AU  - Conio B
FAU - Magioncalda, Paola
AU  - Magioncalda P
FAU - Marozzi, Valentina
AU  - Marozzi V
FAU - Presta, Andrea
AU  - Presta A
FAU - Sterlini, Bruno
AU  - Sterlini B
FAU - Contini, Paola
AU  - Contini P
FAU - Amore, Mario
AU  - Amore M
FAU - Fornaro, Pantaleo
AU  - Fornaro P
FAU - Martino, Matteo
AU  - Martino M
LA  - eng
PT  - Journal Article
DEP - 20141211
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9044SC542W (Duloxetine Hydrochloride)
SB  - IM
CIN - Neurol Sci. 2015 Jun;36(6):1061-2. PMID: 25637063
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*drug therapy
MH  - Duloxetine Hydrochloride/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - Psychiatric Status Rating Scales
MH  - Time Factors
MH  - Young Adult
EDAT- 2014/12/17 06:00
MHDA- 2016/01/20 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2014/12/03 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - 10.1007/s10072-014-2027-7 [doi]
PST - ppublish
SO  - Neurol Sci. 2015 May;36(5):729-34. doi: 10.1007/s10072-014-2027-7. Epub 2014 Dec 
      11.