PMID- 25502751
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 308
IP  - 3
DP  - 2015 Feb 1
TI  - The truncated TrkB receptor influences mammalian sleep.
PG  - R199-207
LID - 10.1152/ajpregu.00422.2014 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophin hypothesized to play 
      an important role in mammalian sleep expression and regulation. In order to 
      investigate the role of the truncated receptor for BDNF, TrkB.T1, in mammalian 
      sleep, we examined sleep architecture and sleep regulation in adult mice 
      constitutively lacking this receptor. We find that TrkB.T1 knockout mice have 
      increased REM sleep time, reduced REM sleep latency, and reduced sleep 
      continuity. These results demonstrate a novel role for the TrkB.T1 receptor in 
      sleep expression and provide new insights into the relationship between BDNF, 
      psychiatric illness, and sleep.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Watson, Adam J
AU  - Watson AJ
AD  - Department of Neuroscience, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania;
FAU - Henson, Kyle
AU  - Henson K
AD  - Department of Neuroscience, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania;
FAU - Dorsey, Susan G
AU  - Dorsey SG
AD  - School of Nursing, University of Maryland, Baltimore, Maryland; and.
FAU - Frank, Marcos G
AU  - Frank MG
AD  - College of Medical Sciences, Sleep and Performance Research Center, Washington 
      State University Spokane, Spokane, Washington marcos.frank@wsu.edu.
LA  - eng
GR  - R37 NS037585/NS/NINDS NIH HHS/United States
GR  - MH-099544/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141210
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Models, Animal
MH  - RNA, Messenger/metabolism
MH  - Receptor, trkB/genetics/*metabolism
MH  - Signal Transduction/*physiology
MH  - Sleep/*physiology
PMC - PMC4313071
OTO - NOTNLM
OT  - REM sleep
OT  - TrkB
OT  - TrkB.T1
OT  - brain-derived neurotrophic factor
OT  - neurotrophins
EDAT- 2014/12/17 06:00
MHDA- 2015/03/25 06:00
PMCR- 2016/02/01
CRDT- 2014/12/16 06:00
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - ajpregu.00422.2014 [pii]
AID - R-00422-2014 [pii]
AID - 10.1152/ajpregu.00422.2014 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2015 Feb 1;308(3):R199-207. doi: 
      10.1152/ajpregu.00422.2014. Epub 2014 Dec 10.