PMID- 25503077
OWN - NLM
STAT- MEDLINE
DCOM- 20150721
LR  - 20231213
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 466
IP  - 3
DP  - 2015 Mar
TI  - Mammary analogue secretory carcinoma of salivary glands: a new entity associated 
      with ETV6 gene rearrangement.
PG  - 245-54
LID - 10.1007/s00428-014-1701-8 [doi]
AB  - Mammary analogue secretory carcinoma (MASC) is a recently described salivary 
      gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This is the 
      first series of MASC cases identified in the historic cohort of carcinomas of 
      salivary glands with clinical/pathological correlation and follow-up data. We 
      reviewed 183 primary carcinomas of major and minor salivary glands resected at 
      the Medical University of Gdansk, Poland, between 1992 and 2012. Based on 
      morphology and immunohistochemistry, cases suspicious for MASC were selected, and 
      the diagnosis was confirmed by fluorescence in situ hybridization (FISH) for ETV6 
      rearrangement and by RT-PCR for the ETV6-NTRK3 fusion transcript. Seven 
      carcinomas met the criteria of MASC, as they exhibited a typical appearance with 
      solid/microcystic and papillary architecture and intraluminal secretions, and 
      cells completely devoid of basophilic cytoplasmic zymogen granules indicative of 
      true acinar differentiation. The only paediatric case was an unencapsulated 
      tumour composed of macrocystic structures covered by a mostly single but, 
      focally, double layer of cells with apocrine morphology. In all cases, the 
      neoplastic cells revealed immunoreactivity for S100, mammaglobin, cytokeratin 
      CK7, CK8, STAT5a and vimentin. FISH for ETV6 gene rearrangement was positive in 
      six out of seven cases, and RT-PCR was positive in three cases. MASC is a new 
      entity of malignant epithelial salivary gland tumours not included in the 2005 
      WHO Classification of Head and Neck Tumours. There is a growing body of evidence 
      that it is not as rare as was assumed, as is also indicated by our series (3.8 
      %). In most cases, MASC shares some microscopic features with AciCC, 
      adenocarcinoma/cystadenocarcinoma NOS and low-grade MEC. In rare cases, MASC with 
      high-grade transformation may mimic the morphological appearances of high-grade 
      salivary gland malignancies, such as salivary duct carcinoma.
FAU - Majewska, Hanna
AU  - Majewska H
AD  - Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland, 
      hania.majewska@gumed.edu.pl.
FAU - Skalova, Alena
AU  - Skalova A
FAU - Stodulski, Dominik
AU  - Stodulski D
FAU - Klimkova, Adela
AU  - Klimkova A
FAU - Steiner, Petr
AU  - Steiner P
FAU - Stankiewicz, Czeslaw
AU  - Stankiewicz C
FAU - Biernat, Wojciech
AU  - Biernat W
LA  - eng
PT  - Journal Article
DEP - 20141212
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (STAT5 Transcription Factor)
RN  - 0 (STAT5A protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (Vimentin)
RN  - 68238-35-7 (Keratins)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - Secretory breast carcinoma
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Breast Neoplasms/*classification/*genetics/metabolism
MH  - Carcinoma/*classification/*genetics/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Fusion/genetics
MH  - Gene Rearrangement/*genetics
MH  - Humans
MH  - Keratins/metabolism
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-ets/*genetics/metabolism
MH  - Receptor, trkC/genetics
MH  - Repressor Proteins/*genetics/metabolism
MH  - Retrospective Studies
MH  - S100 Proteins/metabolism
MH  - STAT5 Transcription Factor/metabolism
MH  - Salivary Gland Neoplasms/*classification/*genetics/metabolism
MH  - Translocation, Genetic/genetics
MH  - Tumor Suppressor Proteins/metabolism
MH  - Vimentin/metabolism
MH  - Young Adult
MH  - ETS Translocation Variant 6 Protein
PMC - PMC4353861
EDAT- 2014/12/17 06:00
MHDA- 2015/07/22 06:00
PMCR- 2014/12/12
CRDT- 2014/12/16 06:00
PHST- 2014/07/23 00:00 [received]
PHST- 2014/11/28 00:00 [accepted]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/07/22 06:00 [medline]
PHST- 2014/12/12 00:00 [pmc-release]
AID - 1701 [pii]
AID - 10.1007/s00428-014-1701-8 [doi]
PST - ppublish
SO  - Virchows Arch. 2015 Mar;466(3):245-54. doi: 10.1007/s00428-014-1701-8. Epub 2014 
      Dec 12.