PMID- 25503442
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20150121
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 11
IP  - 4
DP  - 2015 Apr
TI  - WSKY, a traditional Chinese decoction, rescues cognitive impairment associated 
      with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling.
PG  - 2927-34
LID - 10.3892/mmr.2014.3086 [doi]
AB  - Warm‑supplementing kidney yang (WSKY) is an herbal prescription that has been 
      used in Traditional Chinese Medicine for the treatment of psychiatric conditions. 
      A previous study by our group found that WSKY significantly improved cognitive 
      function of schizophrenia patients. In the present study, the effects of WSKY on 
      cognitive function and their underlying mechanisms were investigated. WSKY was 
      administered to an MK‑801‑induced rat model of chronic schizophrenia for 14 days. 
      Memory performance was assessed using the Morris water maze (MWM) test. The 
      expression of brain‑derived neurotrophic factor (BDNF), activation of cAMP 
      response element binding protein (pCREB/CREB) and activation of extracellular 
      signal‑regulated kinase (pERK/ERK) in the hippocampus was detected using western 
      blot analysis. In the acquisition phase of the MWM test, the escape latency was 
      significantly increased in the MK‑801‑treated group compared with the normal 
      control group (P<0.01). Treatment with WSKY for 14 days at doses of 100 or 250 
      mg/kg rescued this cognitive impairment (P<0.05). In the probe test, 250 mg/kg 
      WSKY treatment increased the time spent in the target quadrant (P<0.05) and 
      number of platform crossings (P<0.01). Western blot analysis demonstrated that 
      the levels of BDNF expression in the hippocampus of rats without behavioral tests 
      were elevated following 14 days of WSKY treatment, and the effect of WSKY 
      treatment on hippocampal BDNF expression was presented in an inverted U‑shaped 
      dose‑response pattern. The pERK1/2 in the hippocampus was significantly enhanced 
      following 100 mg/kg (P<0.01) and 250 mg/kg (P<0.01) WSKY treatment, while only 
      250 mg/kg WSKY increased the phosphorylation of CREB (P<0.01). The results of the 
      present study indicated that WSKY enhances cognitive performance via the 
      upregulation of BDNF/ERK/CREB signaling, and that WSKY has potential therapeutic 
      implications for cognitive impairment of schizophrenia.
FAU - Guo, Xin
AU  - Guo X
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Chen, Zheng-Hua
AU  - Chen ZH
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Wang, Hui-Ling
AU  - Wang HL
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Liu, Zhong-Chun
AU  - Liu ZC
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Wang, Xiao-Ping
AU  - Wang XP
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Zhou, Ben-Hong
AU  - Zhou BH
AD  - Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, 
      P.R. China.
FAU - Yang, Can
AU  - Yang C
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Zhang, Xue-Ping
AU  - Zhang XP
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Xiao, Ling
AU  - Xiao L
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Shu, Chang
AU  - Shu C
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Chen, Jian-Xin
AU  - Chen JX
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
FAU - Wang, Gao-Hua
AU  - Wang GH
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430060, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141212
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cognition Disorders/drug therapy/genetics/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/administration & dosage/chemistry/*pharmacology
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Memory/drug effects
MH  - Phosphorylation
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Signal Transduction/*drug effects
MH  - Spatial Learning/drug effects
EDAT- 2014/12/17 06:00
MHDA- 2015/09/29 06:00
CRDT- 2014/12/16 06:00
PHST- 2013/11/30 00:00 [received]
PHST- 2014/05/30 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
AID - 10.3892/mmr.2014.3086 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Apr;11(4):2927-34. doi: 10.3892/mmr.2014.3086. Epub 2014 Dec 
      12.