PMID- 25504263
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20220801
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 15
IP  - 2
DP  - 2015 Feb
TI  - Immune reconstitution inflammatory syndrome associated with biologic therapy.
PG  - 499
LID - 10.1007/s11882-014-0499-4 [doi]
AB  - The use of biologics in the treatment of autoimmune disease, cancer, and other 
      immune conditions has revolutionized medical care in these areas. However, there 
      are drawbacks to the use of these medications including increased susceptibility 
      to opportunistic infections. One unforeseen risk once opportunistic infection has 
      occurred with biologic use is the onset of immune reconstitution inflammatory 
      syndrome (IRIS) upon drug withdrawal. Although originally described in human 
      immunodeficiency virus (HIV) patients receiving highly active antiretroviral 
      therapy, it has become clear that IRIS may occur when recovery of immune function 
      follows opportunistic infection in the setting of previous immune 
      compromise/suppression. In this review, we draw attention to this potential 
      pitfall on the use of biologic drugs.
FAU - Gupta, Malika
AU  - Gupta M
AD  - Division of Allergy and Immunology, Children's Hospital of Philadelphia, 
      Philadelphia, PA, USA.
FAU - Jafri, Kashif
AU  - Jafri K
FAU - Sharim, Rebecca
AU  - Sharim R
FAU - Silverman, Susanna
AU  - Silverman S
FAU - Sindher, Sayantani B
AU  - Sindher SB
FAU - Shahane, Anupama
AU  - Shahane A
FAU - Kwan, Mildred
AU  - Kwan M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Antibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antibodies/adverse effects
MH  - Biological Therapy/*adverse effects
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*immunology
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
EDAT- 2014/12/17 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1007/s11882-014-0499-4 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2015 Feb;15(2):499. doi: 10.1007/s11882-014-0499-4.