PMID- 25505388
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141216
LR  - 20200930
IS  - 1662-5129 (Print)
IS  - 1662-5129 (Electronic)
IS  - 1662-5129 (Linking)
VI  - 8
DP  - 2014
TI  - Signaling mechanisms and behavioral function of the mouse basal vomeronasal 
      neuroepithelium.
PG  - 135
LID - 10.3389/fnana.2014.00135 [doi]
LID - 135
AB  - The vomeronasal organ (VNO) is a sensory organ that is found in most terrestrial 
      vertebrates and that is principally implicated in the detection of pheromones. 
      The VNO contains specialized sensory neurons organized in a pseudostratified 
      neuroepithelium that recognize chemical signals involved in initiating innate 
      behavioral responses. In rodents, the VNO neuroepithelium is segregated into two 
      distinct zones, apical and basal. The molecular mechanisms involved in ligand 
      detection by apical and basal VNO sensory neurons differ extensively. These two 
      VNO subsystems express different subfamilies of vomeronasal receptors and 
      signaling molecules, detect distinct chemosignals, and project to separate 
      regions of the accessory olfactory bulb (AOB). The roles that these olfactory 
      subdivisions play in the control of specific olfactory-mediated behaviors are 
      largely unclear. However, analysis of mutant mouse lines for signal transduction 
      components together with identification of defined chemosensory ligands has 
      revealed a fundamental role of the basal part of the mouse VNO in mediating a 
      wide range of instinctive behaviors, such as aggression, predator avoidance, and 
      sexual attraction. Here we will compare the divergent functions and synergies 
      between the olfactory subsystems and consider new insights in how higher neural 
      circuits are defined for the initiation of instinctive behaviors.
FAU - Perez-Gomez, Anabel
AU  - Perez-Gomez A
AD  - Department of Physiology, University of Saarland School of Medicine Homburg, 
      Saarland, Germany.
FAU - Stein, Benjamin
AU  - Stein B
AD  - Department of Physiology, University of Saarland School of Medicine Homburg, 
      Saarland, Germany.
FAU - Leinders-Zufall, Trese
AU  - Leinders-Zufall T
AD  - Department of Physiology, University of Saarland School of Medicine Homburg, 
      Saarland, Germany.
FAU - Chamero, Pablo
AU  - Chamero P
AD  - Department of Physiology, University of Saarland School of Medicine Homburg, 
      Saarland, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141126
PL  - Switzerland
TA  - Front Neuroanat
JT  - Frontiers in neuroanatomy
JID - 101477943
PMC - PMC4244706
OTO - NOTNLM
OT  - Galphao signaling
OT  - V2R
OT  - behavior
OT  - olfaction
OT  - peptides
OT  - pheromone
OT  - vomeronasal organ
EDAT- 2014/12/17 06:00
MHDA- 2014/12/17 06:01
PMCR- 2014/01/01
CRDT- 2014/12/16 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2014/11/03 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2014/12/17 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnana.2014.00135 [doi]
PST - epublish
SO  - Front Neuroanat. 2014 Nov 26;8:135. doi: 10.3389/fnana.2014.00135. eCollection 
      2014.