PMID- 25506383
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141216
LR  - 20220330
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2014
DP  - 2014
TI  - Sodium hydrosulfide relieves neuropathic pain in chronic constriction injured 
      rats.
PG  - 514898
LID - 10.1155/2014/514898 [doi]
LID - 514898
AB  - Aberrant neuronal activity in injured peripheral nerves is believed to be an 
      important factor in the development of neuropathic pain (NPP). Channel protein 
      pCREB of that activity has been shown to mitigate the onset of associated 
      molecular events in the nervous system, and sodium hydrosulfide (NaHS) could 
      inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it 
      needs further experimental research. Furthermore, the clinical potential that 
      NaHS was used to relieve pain was limited so it would be required. To address 
      these issues, the rats of sciatic nerve chronic constriction injury (CCI) were 
      given intraperitoneal injection of NaHS containing hydrogen sulfide (H2S). The 
      experimental results showed that NaHS inhibited the reduction of paw withdrawal 
      thermal latency (PWTL), mechanical withdrawal threshold (MWT), and the level of 
      pCREB in CCI rats in a dose-dependent manner and they were greatly decreased in 
      NaHSM group (P < 0.05). NaHS alleviates chronic neuropathic pain by inhibiting 
      expression of pCREB in the spinal cord of Sprague-Dawley rats.
FAU - Lin, Jian-Qing
AU  - Lin JQ
AD  - Department of Anesthesiology, The First Hospital of Fujian Medical University, 
      Fuzhou 350005, China.
FAU - Luo, Hui-Qin
AU  - Luo HQ
AD  - Department of Anesthesiology, The Affiliated People's Hospital of Fujian 
      University of Traditional Chinese Medicine, Fuzhou 350005, China.
FAU - Lin, Cai-Zhu
AU  - Lin CZ
AD  - Department of Anesthesiology, The First Hospital of Fujian Medical University, 
      Fuzhou 350005, China.
FAU - Chen, Jin-Zhuan
AU  - Chen JZ
AD  - Department of Anesthesiology, The First Hospital of Fujian Medical University, 
      Fuzhou 350005, China.
FAU - Lin, Xian-Zhong
AU  - Lin XZ
AD  - Department of Anesthesiology, The First Hospital of Fujian Medical University, 
      Fuzhou 350005, China.
LA  - eng
PT  - Journal Article
DEP - 20141125
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4260443
EDAT- 2014/12/17 06:00
MHDA- 2014/12/17 06:01
PMCR- 2014/11/25
CRDT- 2014/12/16 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2014/09/07 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2014/12/17 06:01 [medline]
PHST- 2014/11/25 00:00 [pmc-release]
AID - 10.1155/2014/514898 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2014;2014:514898. doi: 10.1155/2014/514898. 
      Epub 2014 Nov 25.