PMID- 25506717
OWN - NLM
STAT- MEDLINE
DCOM- 20151104
LR  - 20150114
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 7
IP  - 1
DP  - 2015 Jan 14
TI  - Mesoporous organosilica nanoparticles containing superacid and click 
      functionalities leading to cooperativity in biocidal coatings.
PG  - 1021-9
LID - 10.1021/am5083057 [doi]
AB  - A superior degree of functionality in materials can be expected, if two or more 
      operational entities are related in a cooperative form. It is obvious that, for 
      this purpose, one is seeking materials with complex design comprising bi- or 
      multiple functional groups complementing each other. In the current paper, it is 
      demonstrated that periodically ordered mesoporous organosilicas (PMOs) based on 
      co-condensation of sol-gel precursors with bridging phenyl derivatives 
      RF1,2C6H3[Si(O(iso)Pr)3]2 allow for rich opportunities in providing high-surface 
      area materials with such a special chemical architecture. PMOs containing high 
      density of thiol ( congruent with RF1) and sulfonic acid units ( congruent with RF2) were prepared as 
      mesoporous nanoparticles via an aerosol-assisted gas-phase method and were tested 
      for biocidal applications. Each of the mentioned organic groups fulfills several 
      tasks at once. The selective functionalization of thiols located at the surface 
      of the particles using click chemistry leads to durable grafting on different 
      substrates like glass or stainless steel, and the intraparticle -SH groups are 
      important regarding the uptake of metal ions like Ag(+) and for immobilization of 
      Ag(0) nanoparticles inside the pores as an enduring reservoir for antibacterial 
      force. The superacidic sulfonic acid groups exhibit a strong and instantaneous 
      biocidal acitivity, and they are important for adjusting the Ag(+) release rate. 
      Biological studies involving inhibitory investigation tests (MIC), fluorescence 
      microscopy (life/dead staining), and bacterial adhesion tests with Pseudomonas 
      aeruginosa show that the organobifunctional materials present much better 
      performance against biofilm formation compared to materials containing only one 
      of the above-mentioned groups.
FAU - Gehring, Julia
AU  - Gehring J
AD  - Department of Chemistry and double daggerDepartment of Biology, University of Konstanz , 
      D-78457 Konstanz, Germany.
FAU - Schleheck, David
AU  - Schleheck D
FAU - Trepka, Bastian
AU  - Trepka B
FAU - Polarz, Sebastian
AU  - Polarz S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141229
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Ions)
RN  - 0 (Organosilicon Compounds)
RN  - 0 (Powders)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Sulfonic Acids)
SB  - IM
MH  - Anti-Bacterial Agents/chemistry
MH  - Biofilms/*drug effects
MH  - *Click Chemistry
MH  - Hydrogen-Ion Concentration
MH  - Ions
MH  - Materials Testing
MH  - Metal Nanoparticles/*chemistry
MH  - Microbial Sensitivity Tests
MH  - Microscopy, Electron, Transmission
MH  - Microscopy, Fluorescence
MH  - Nanotechnology/*methods
MH  - Organosilicon Compounds/*chemistry
MH  - Powders
MH  - Pseudomonas aeruginosa/drug effects
MH  - Reproducibility of Results
MH  - Spectrophotometry
MH  - Sulfhydryl Compounds/chemistry
MH  - Sulfonic Acids/chemistry
MH  - Surface Properties
OTO - NOTNLM
OT  - antifouling
OT  - click chemistry
OT  - mesoporous particles
OT  - multifunctional materials
OT  - surface immobilization
EDAT- 2014/12/17 06:00
MHDA- 2015/11/05 06:00
CRDT- 2014/12/16 06:00
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/11/05 06:00 [medline]
AID - 10.1021/am5083057 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2015 Jan 14;7(1):1021-9. doi: 10.1021/am5083057. Epub 
      2014 Dec 29.