PMID- 25506838
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 12
DP  - 2014
TI  - Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: a 
      neuroimaging and neurotrophin study.
PG  - e114909
LID - 10.1371/journal.pone.0114909 [doi]
LID - e114909
AB  - BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In 
      this study, we attempted to identify the neuroprotective mechanism of BNG-1 by 
      using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were 
      treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery 
      occlusion by filament model. The temporal change of magnetic resonance (MR) 
      imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the 
      temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor 
      (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and 
      at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 
      group exhibited a smaller infarction volume in the cerebral cortex in T2 image 
      from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image 
      from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the 
      cortex and striatum in perfusion image at 4 h, and earlier normalization of the 
      ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 
      and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We 
      concluded that the protective effect of BNG-1 against cerebral ischemic injury 
      might act through improving cerebral hemodynamics and recovering neurotrophin 
      generation.
FAU - Chi, Nai-Fang
AU  - Chi NF
AD  - Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New 
      Taipei City, Taiwan, and Department of Neurology, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Liu, Ho-Ling
AU  - Liu HL
AD  - Department of Medical Imaging and Radiological Sciences, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan.
FAU - Yang, Jen-Tsung
AU  - Yang JT
AD  - Department of Neurosurgery, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan, 
      and Department of Neurosurgery, Chang Gung University College of Medicine, 
      Taoyuan, Taiwan.
FAU - Lin, Jr-Rung
AU  - Lin JR
AD  - Clinical Informatics and Medical Statistics Research Center, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Liao, Shu-Li
AU  - Liao SL
AD  - Department of Traditional Chinese Medicine, Taoyuan General Hospital, Ministry of 
      Health and Welfare, Taoyuan, Taiwan.
FAU - Peng, Bo-Han
AU  - Peng BH
AD  - Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou 
      Medical Center, Taoyuan, Taiwan.
FAU - Lee, Yen-Tung
AU  - Lee YT
AD  - Department of Traditional Chinese Medicine, En Chu Kong Hospital, New Taipei 
      City, Taiwan.
FAU - Lee, Tsong-Hai
AU  - Lee TH
AD  - Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou 
      Medical Center, Taoyuan, Taiwan, and Chang Gung University College of Medicine, 
      Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141215
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/*pathology
MH  - Brain Ischemia/*drug therapy/pathology
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Infarction, Middle Cerebral Artery/drug therapy/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Growth Factor/analysis
MH  - Neuroimaging
MH  - Neuroprotective Agents/*therapeutic use
MH  - Neurotrophin 3/analysis
MH  - Phosphodiesterase Inhibitors/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC4266630
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/12/17 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/12/15
CRDT- 2014/12/16 06:00
PHST- 2014/04/25 00:00 [received]
PHST- 2014/11/15 00:00 [accepted]
PHST- 2014/12/16 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
AID - PONE-D-14-06004 [pii]
AID - 10.1371/journal.pone.0114909 [doi]
PST - epublish
SO  - PLoS One. 2014 Dec 15;9(12):e114909. doi: 10.1371/journal.pone.0114909. 
      eCollection 2014.