PMID- 25510699 OWN - NLM STAT- MEDLINE DCOM- 20150825 LR - 20191210 IS - 1875-6263 (Electronic) IS - 1028-4559 (Linking) VI - 53 IP - 4 DP - 2014 Dec TI - Comparison of early-stage primary serous fallopian tube carcinomas and equivalent stage serous epithelial ovarian carcinomas. PG - 547-51 LID - S1028-4559(14)00187-9 [pii] LID - 10.1016/j.tjog.2014.06.002 [doi] AB - OBJECTIVE: To investigate the outcome of patients with early-stage primary fallopian tube carcinomas (PFTC) and those of patients with equivalent-stage serous epithelial ovarian carcinomas (SEOC). MATERIALS AND METHODS: A balanced and matched, case-control comparison was conducted in a university-based tertiary hospital database between 1978 and 2007. All PFTC and SEOC patients were treated with complete staging surgery followed by multiagent chemotherapy. One SEOC control was matched for each PFTC patient in a very uniform manner (characteristics and treatment). Disease-free survival (DFS) and overall survival (OS) were then compared using Kaplan-Meier analysis. RESULTS: Twenty-six paired patients were analyzed. Patients with PFTC were significantly older than the SEOC patients (58 years vs. 51 years, p = 0.001). In terms of recurrence, PFTC patients frequently had an extra-abdominal metastasis (3/4, 75%), in contrast to the SEOC patients, who did not (1/5, 20%). The 5-year DFS rate was similar in both groups (85% vs. 81%, p = 0.05), contributing to a similar OS rate (89% vs. 85%, p = 0.50). The median DFS and OS of patients with PFTC and SEOC were also similar without a statistically significant difference (125 months vs. 109 months, and 125 months vs. 122 months, respectively). CONCLUSION: Our study demonstrated that the survival outcome of International Federation of Gynecology and Obstetrics (FIGO) I/II PFTC patients was similar to that of FIGO I/II SEOC patients, and both groups had a >80% 5-year DFS rate after complete staging surgery, followed by multiagent chemotherapy. This finding is worthy of being investigated. CI - Copyright (c) 2014. Published by Elsevier B.V. FAU - Horng, Huann-Cheng AU - Horng HC AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Lai, Chiung-Ru AU - Lai CR AD - Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pathology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Chang, Wen-Hsun AU - Chang WH AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Nursing, National Yang-Ming University School of Nursing, Taipei, Taiwan; Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Wen, Kuo-Chang AU - Wen KC AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Chen, Yi-Jen AU - Chen YJ AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Juang, Chi-Mou AU - Juang CM AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Yen, Ming-Shyen AU - Yen MS AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Wang, Peng-Hui AU - Wang PH AD - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Nursing, National Yang-Ming University School of Nursing, Taipei, Taiwan; Immunology Center, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address: phwang@vghtpe.gov.tw. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China (Republic : 1949- ) TA - Taiwan J Obstet Gynecol JT - Taiwanese journal of obstetrics & gynecology JID - 101213819 RN - 0 (Antineoplastic Agents) SB - IM MH - Adult MH - Aged MH - Antineoplastic Agents/administration & dosage MH - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use MH - Carcinoma, Ovarian Epithelial MH - Chemotherapy, Adjuvant MH - Cystadenocarcinoma, Serous/mortality/pathology/*therapy MH - Databases, Factual MH - Fallopian Tube Neoplasms/mortality/pathology/*therapy MH - Female MH - Follow-Up Studies MH - Humans MH - Matched-Pair Analysis MH - Middle Aged MH - Neoplasm Staging MH - Neoplasms, Glandular and Epithelial/mortality/pathology/*therapy MH - Ovarian Neoplasms/mortality/pathology/*therapy MH - *Ovariectomy MH - Retrospective Studies MH - *Salpingectomy MH - Survival Analysis MH - Treatment Outcome OTO - NOTNLM OT - case-control study OT - early stage OT - outcome OT - primary fallopian tube carcinoma OT - serous epithelial ovarian carcinoma EDAT- 2014/12/17 06:00 MHDA- 2015/08/26 06:00 CRDT- 2014/12/17 06:00 PHST- 2014/06/27 00:00 [accepted] PHST- 2014/12/17 06:00 [entrez] PHST- 2014/12/17 06:00 [pubmed] PHST- 2015/08/26 06:00 [medline] AID - S1028-4559(14)00187-9 [pii] AID - 10.1016/j.tjog.2014.06.002 [doi] PST - ppublish SO - Taiwan J Obstet Gynecol. 2014 Dec;53(4):547-51. doi: 10.1016/j.tjog.2014.06.002.