PMID- 25510832
OWN - NLM
STAT- MEDLINE
DCOM- 20160122
LR  - 20150224
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 71
IP  - 2
DP  - 2015 Mar
TI  - Derivation of exposure factors for infant lactational exposure to persistent 
      organic pollutants (POPs).
PG  - 135-40
LID - S0273-2300(14)00296-7 [pii]
LID - 10.1016/j.yrtph.2014.12.003 [doi]
AB  - Quantifying the influence of breastfeeding on infant's dose and biological levels 
      is critical for the risk assessment of persistent organic pollutant (POP) early 
      exposures. We aimed to quantify infants' exposure relative to the mother for 
      POPs. Using a validated pharmacokinetic model, Monte-Carlo simulations of 
      infants' exposure during the first 2 years of life for POPs of different 
      half-lives (i.e., 1-20 years) were performed. Infant:mother (I:M) ratios for dose 
      and biological levels throughout infancy were derived. To evaluate model 
      accuracy, simulated I:M biological level ratios were compared to ratios 
      calculated from Inuit mothers' and infants' measured plasma levels of 
      2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), 
      p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB). 
      Practically all measured I:M biological level ratios from the Inuit cohort fell 
      below the 95th percentile of the distributions of simulated PCB-153, p,p'-DDE and 
      HCB levels. Peak I:M dose ratios were observed at the beginning of lactation with 
      95th percentile values of 13, 53, 84, 102 and 113 for half-lives of 1, 5, 10, 15 
      and 20 years, respectively. In contrast, peak I:M biological level ratios 
      occurred after approximately 1 year of breastfeeding and plateaued at 
      approximately 10.5 (95th percentile) for chemicals of half-lives >5 years. 
      Simulated I:M dose and biological level ratios could be employed in risk 
      assessment of early POP exposures through breastfeeding.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Haddad, Sami
AU  - Haddad S
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Universite de Montreal, Montreal, QC, Canada; Universite de Montreal Public 
      Health Research Institute (IRSPUM), Universite de Montreal, Montreal, QC, Canada; 
      Chair in Toxicological Risk Assessment and Management, Universite de Montreal, 
      Montreal, QC, Canada. Electronic address: sami.haddad@umontreal.ca.
FAU - Ayotte, Pierre
AU  - Ayotte P
AD  - Axe sante des populations et pratiques optimales en sante, Centre de recherche du 
      CHU de Quebec, Quebec, QC, Canada; Departement de medecine sociale et preventive, 
      Universite Laval, Quebec, QC, Canada.
FAU - Verner, Marc-Andre
AU  - Verner MA
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Universite de Montreal, Montreal, QC, Canada; Universite de Montreal Public 
      Health Research Institute (IRSPUM), Universite de Montreal, Montreal, QC, Canada; 
      Chair in Toxicological Risk Assessment and Management, Universite de Montreal, 
      Montreal, QC, Canada; Department of Environmental Health, Harvard School of 
      Public Health, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141212
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Breast Feeding/*adverse effects/trends
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lactation/drug effects/metabolism
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - *Models, Biological
MH  - Monte Carlo Method
OTO - NOTNLM
OT  - Breast milk
OT  - Exposure
OT  - Exposure factor
OT  - Infant
OT  - Infant:mother ratio
OT  - PBPK modeling
OT  - Persistent organic pollutants
OT  - Pharmacokinetic
OT  - Risk assessment
OT  - Variability
EDAT- 2014/12/17 06:00
MHDA- 2016/01/23 06:00
CRDT- 2014/12/17 06:00
PHST- 2014/10/01 00:00 [received]
PHST- 2014/12/05 00:00 [revised]
PHST- 2014/12/06 00:00 [accepted]
PHST- 2014/12/17 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2016/01/23 06:00 [medline]
AID - S0273-2300(14)00296-7 [pii]
AID - 10.1016/j.yrtph.2014.12.003 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2015 Mar;71(2):135-40. doi: 10.1016/j.yrtph.2014.12.003. 
      Epub 2014 Dec 12.