PMID- 25510949
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20220321
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Print)
IS  - 1180-4882 (Linking)
VI  - 40
IP  - 3
DP  - 2015 May
TI  - The risk for major depression conferred by childhood maltreatment is multiplied 
      by BDNF and SERT genetic vulnerability: a replication study.
PG  - 187-96
AB  - BACKGROUND: There is limited evidence for a moderating role of both serotonin 
      transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk 
      for major depression (MD) developing after childhood maltreatment. However, 
      research on this topic remains inconclusive, and there is a lack of data from 
      longitudinal studies with large and representative population samples. Our study 
      aimed to clarify whether, in the presence of previous childhood maltreatment, 
      individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF 
      Val66Met polymorphisms had a higher risk for MD. METHODS: We explored 2- and 
      3-way gene (SERT and BDNF) x environment (childhood maltreatment) interactions in 
      a large sample of Spanish adults who were followed up over a 3-year period and 
      assessed in person for both DSM-IV MD and exposure to childhood maltreatment. 
      RESULTS: Our study included 2679 participants. Those with both the 5-HTTLPR s 
      allele and the BDNF Met allele showed the highest risk of MD if they had 
      previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 
      0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). These 3-way 
      interactions remained significant regardless of whether the 5-HTTLPR triallelic 
      or the 5-HTTLPR biallelic polymorphisms were included in the analyses. 
      LIMITATIONS: Retrospective assessment of childhood maltreatment may have resulted 
      in a moderate degree of recall bias. CONCLUSION: Our results confirm that the 
      risk of depression conferred by childhood maltreatment is modified by variation 
      at both SERT and BDNF genes.
FAU - Gutierrez, Blanca
AU  - Gutierrez B
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM-University of 
      Granada), the Institute of Neurosciences Federico Oloriz, Centro de Investigacion 
      Biomedica, the Department of Psychiatry, School of Medicine, University of 
      Granada, Spain, and the MRC Social, Genetic and Developmental Psychiatry (SGDP) 
      Centre, Institute of Psychiatry, King s College London, United Kingdom.
FAU - Bellon, Juan A
AU  - Bellon JA
AD  - Centro de Salud El Palo. Departamento de Medicina Preventiva y Salud Publica. 
      Universidad de Malaga and the Unidad de Investigacion del Distrito de Atencion 
      Primaria de Malaga (redIAPP, grupo SAMSERAP), Spain.
FAU - Rivera, Margarita
AU  - Rivera M
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM-University of 
      Granada), Spain, and the MRC Social, Genetic and Developmental Psychiatry (SGDP) 
      Centre, Institute of Psychiatry, King s College London, United Kingdom.
FAU - Molina, Esther
AU  - Molina E
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM-University of 
      Granada) and the Institute of Neurosciences Federico Oloriz, Centro de 
      Investigacion Biomedica, University of Granada, Spain.
FAU - King, Michael
AU  - King M
AD  - Mental Health Sciences, Faculty of Brain Sciences, UCL, UK.
FAU - Marston, Louise
AU  - Marston L
AD  - Research Department of Primary Care and Population Health, UCL, UK.
FAU - Torres-Gonzalez, Francisco
AU  - Torres-Gonzalez F
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM-University of 
      Granada), and the Department of Psychiatry, School of Medicine, University of 
      Granada, Spain.
FAU - Moreno-Kustner, Berta
AU  - Moreno-Kustner B
AD  - Dpto. Personalidad, Evaluacion y Tratamiento Psicologico, Grupo GAP. Facultad de 
      Psicologia, Universidad de Malaga, Spain.
FAU - Moreno-Peral, Patricia
AU  - Moreno-Peral P
AD  - Unidad de Investigacion del Distrito de Atencion Primaria de Malaga (redIAPP, 
      grupo SAMSERAP), Spain.
FAU - Motrico, Emma
AU  - Motrico E
AD  - Universidad Loyola Andalucia and Departamento de Psicologia Evolutiva y de la 
      Educacion de la Universidad de Sevilla, Sevilla, Spain.
FAU - Monton-Franco, Carmen
AU  - Monton-Franco C
AD  - Centro de Salud Casablanca. (redIAPP, grupo Aragon) Departamento de Medicina y 
      Psiquiatria. Universidad de Zaragoza, Spain.
FAU - GildeGomez-Barragan, Maria J
AU  - GildeGomez-Barragan MJ
AD  - Unidad Docente de Medicina Familiar y Comunitaria de La Rioja. Servicio Riojano 
      de la Salud, Logrono, La Rioja. Spain.
FAU - Sanchez-Celaya, Marta
AU  - Sanchez-Celaya M
AD  - Directora Continuidad Asistencial Hospital Universitario Infanta Sofia, Madrid.
FAU - Diaz-Barreiros, Miguel A
AU  - Diaz-Barreiros MA
AD  - Centro de Salud Vecindario, Gerencia de Atencion Primaria de Gran Canaria, 
      Servicio Canario de Salud, Las Palmas, Spain.
FAU - Vicens, Catalina
AU  - Vicens C
AD  - Centro de Salud son Serra-La Vileta. Unidad Docente de Medicina Familiar y 
      Comunitaria de Mallorca. Instituto Balear de la Salud (redIAPP, grupo Baleares), 
      Palma de Mallorca, Illes Balears, Spain.
FAU - de Dios Luna, Juan
AU  - de Dios Luna J
AD  - Departamento de Bioestadistica, Universidad de Granada, Spain.
FAU - Nazareth, Irwin
AU  - Nazareth I
AD  - Mental Health Sciences, Faculty of Brain Sciences, UCL, UK.
FAU - Cervilla, Jorge
AU  - Cervilla J
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM-University of 
      Granada), the Institute of Neurosciences Federico Oloriz, Centro de Investigacion 
      Biomedica, University of Granada, the Department of Psychiatry, School of 
      Medicine, University of Granada, Hospital Universitario Clinico San Cecilio, the 
      Granada, Spain, and the MRC Social, Genetic and Developmental Psychiatry (SGDP) 
      Centre, Institute of Psychiatry, King s College London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - *Child Abuse
MH  - Depressive Disorder, Major/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene-Environment Interaction
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Spain
PMC - PMC4409436
EDAT- 2014/12/17 06:00
MHDA- 2015/10/16 06:00
PMCR- 2015/05/01
CRDT- 2014/12/17 06:00
PHST- 2014/12/17 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1503/jpn.140097 [pii]
AID - jpn-40-187 [pii]
AID - 10.1503/jpn.140097 [doi]
PST - ppublish
SO  - J Psychiatry Neurosci. 2015 May;40(3):187-96. doi: 10.1503/jpn.140097.