PMID- 25512222
OWN - NLM
STAT- MEDLINE
DCOM- 20151005
LR  - 20201209
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 14
DP  - 2014 Dec 16
TI  - Expression of NALPs in adipose and the fibrotic progression of non-alcoholic 
      fatty liver disease in obese subjects.
PG  - 208
LID - 10.1186/s12876-014-0208-8 [doi]
LID - 208
AB  - BACKGROUND: Visceral obesity is often accompanied by non-alcoholic fatty liver 
      disease (NAFLD). Activation of NACHT, LRR and PYD domains-containing proteins 
      (NALPs) may contribute to the release of pro-inflammatory cytokines by adipose 
      and the obesity-associated progression of NAFLD to non-alcoholic steatohepatitis 
      (NASH). METHODS: We analyzed visceral adipose expression of various NALPs and its 
      downstream effectors caspase-1, ASC (Apoptosis-associated speck-like protein 
      containing a CARD), IL-18 (Interleukin-18) and IL-1beta (Interleukin- 1Beta) in 
      obese subjects (BMI >/= 35) with biopsy proven NAFLD. RESULTS: In adipose samples 
      collected from NASH and pericellular fibrosis patients cohorts, expression levels 
      of NALPs and IL-1beta were lower than that in non-NASH patients. In portal fibrosis, 
      the levels of mRNA encoding anti-inflammatory NALP6 were upregulated. The 
      expression levels of all NALPs were significantly co-correlated. Circulating 
      IL-18 levels were associated with increased liver injury markers AST and ALT and 
      portal fibrosis. CONCLUSION: Our observations point at a possible shift in 
      inflammation and fibrotic response from adipose tissue to liver and a possible 
      negative feedback regulation of tissue inflammation that may instigate NAFLD 
      severity.
FAU - Mehta, Rohini
AU  - Mehta R
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. mehta.rohini@gmail.com.
AD  - Center for the Study of Chronic Metabolic Diseases, School of Systems Biology, 
      College of Science, George Mason University, Fairfax, VA, USA. 
      mehta.rohini@gmail.com.
FAU - Neupane, Arpan
AU  - Neupane A
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. aneupane14@gmail.com.
AD  - Center for the Study of Chronic Metabolic Diseases, School of Systems Biology, 
      College of Science, George Mason University, Fairfax, VA, USA. 
      aneupane14@gmail.com.
FAU - Wang, Lei
AU  - Wang L
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. wanglei131@gmail.com.
AD  - Center for the Study of Chronic Metabolic Diseases, School of Systems Biology, 
      College of Science, George Mason University, Fairfax, VA, USA. 
      wanglei131@gmail.com.
FAU - Goodman, Zachary
AU  - Goodman Z
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. zachary.goodman@inova.org.
AD  - Center for Liver Diseases and Department of Medicine, Inova Fairfax Hospital, 
      Falls Church, VA, USA. zachary.goodman@inova.org.
FAU - Baranova, Ancha
AU  - Baranova A
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. aancha@gmail.com.
AD  - Center for the Study of Chronic Metabolic Diseases, School of Systems Biology, 
      College of Science, George Mason University, Fairfax, VA, USA. aancha@gmail.com.
FAU - Younossi, Zobair M
AU  - Younossi ZM
AD  - Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls 
      Church, VA, USA. zobair.younossi@inova.org.
AD  - Center for Liver Diseases and Department of Medicine, Inova Fairfax Hospital, 
      Falls Church, VA, USA. zobair.younossi@inova.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141216
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NLRP4 protein, human)
RN  - 0 (NLRP6 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Caspase 1/metabolism
MH  - Disease Progression
MH  - Down-Regulation
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Inflammasomes/metabolism
MH  - Interleukin-18/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*complications/*metabolism/pathology
MH  - Obesity/*complications/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Repressor Proteins/metabolism
MH  - Up-Regulation
PMC - PMC4279907
EDAT- 2014/12/17 06:00
MHDA- 2015/10/06 06:00
PMCR- 2014/12/16
CRDT- 2014/12/17 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/11/27 00:00 [accepted]
PHST- 2014/12/17 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/10/06 06:00 [medline]
PHST- 2014/12/16 00:00 [pmc-release]
AID - s12876-014-0208-8 [pii]
AID - 208 [pii]
AID - 10.1186/s12876-014-0208-8 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2014 Dec 16;14:208. doi: 10.1186/s12876-014-0208-8.