PMID- 25512284
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20181202
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 46
IP  - 6
DP  - 2014 Dec 18
TI  - [Correlation between urinary sediment spectra and pathological patterns of renal 
      biopsies].
PG  - 920-5
AB  - OBJECTIVE: To investigate the clinical value of urinary sediment analysis, a 
      non-invasive diagnostic means, in the evaluation of pathological patterns of 
      renal diseases. METHODS: A total of 1 140 pairs of matched renal biopsies and 
      fresh fasting morning urine specimens were collected from hospitalized patients 
      in Peking University First Hospital. Their urinary sediments were examined with 
      phase-contrast microscopy; the 24 h urine proteins were measured. Based on 
      urinary sediment features combined with urine protein amount, the spectra of the 
      urine sediments were classified into four types, Type I: hematuria-dominant, with 
      multiple cells and casts; Type II: proteinuria-dominant, with hyaline or 
      fine-granular casts but scanty cells; Type III: renal tubular epithelial 
      cell(RTEC)-dominant, minor proteinuria; Type IV: non-specificurine 
      sediments,minor proteinuria. According to the pathological lesions detected in 
      renal biopsies, the renal diseases were classified into three patterns: 
      proliferative glomerulopathy(P-GP), non-proliferative glomerulopathy (NP-GP) and 
      tubulointerstitial nephropathy(TIN). The urinary sediment spectra of different 
      pathological patterns and the correlation between urinary sediment types and 
      pathological patterns were analyzed. Statistical analyses were performed using 
      kappa test, and chi(2) test, and significance was accepted at P<0.05. RESULTS: (1) 
      Of the 840 cases of matched urine samples and renal biopsies, 419 cases were 
      diagnosed with P-GP; 375 cases with NP-GP; 46 cases with TIN respectively. (2) 
      The spectra of urine sediments were associated with pathological patterns of the 
      renal biopsies, and 84.0% of the patients with P-GP manifested type I urine 
      sediments; 93.1% of the patients with NP-GP had type II urine sediments; 67.4% of 
      the patients with TIN had type III urine sediments. (3) The correlation between 
      the urinary sediment types and renal pathological patterns was validated in an 
      additional 300 matched samples. The positive predictive values of urinary 
      sediment spectra in predicting renal pathological lesions were 84.8% for typeI to 
      P-GP, 86.0% for type II to NP-GP and 73.7% for type III to TIN, respectively. 
      CONCLUSION: As a non-invasive diagnostic means, the urinary sediment analysis is 
      valuable in the evaluation of pathological patterns of renal diseases.
FAU - Li, J Z
AU  - Li JZ
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
FAU - Wang, S X
AU  - Wang SX
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
FAU - Qin, X Q
AU  - Qin XQ
AD  - Department of Biostatistics, Peking University First Hospital,Beijing 
      100034,China.
FAU - Xu, Y
AU  - Xu Y
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
FAU - Pang, W
AU  - Pang W
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
FAU - E, J
AU  - E J
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
FAU - Zheng, X
AU  - Zheng X
AD  - Renal Division, Department of Medicine, Peking University First Hospital; 
      Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, 
      Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention 
      and Treatment, Ministry of Education,Beijing 100034, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
SB  - IM
MH  - Biopsy
MH  - Epithelial Cells
MH  - Hematuria
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Diseases/*diagnosis
MH  - Proteinuria
MH  - *Urinalysis
EDAT- 2014/12/17 06:00
MHDA- 2015/09/09 06:00
CRDT- 2014/12/17 06:00
PHST- 2014/12/17 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Dec 18;46(6):920-5.