PMID- 25512800
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141216
LR  - 20200930
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 5
IP  - 6
DP  - 2014 Dec 15
TI  - Type 2 diabetes is associated with a worse functional outcome of ischemic stroke.
PG  - 939-44
LID - 10.4239/wjd.v5.i6.939 [doi]
AB  - AIM: To assess whether ischemic stroke severity and outcome is more adverse in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: Consecutive patients 
      hospitalized for acute ischemic stroke between September 2010 and June 2013 were 
      studied prospectively (n = 482; 40.2% males, age 78.8 +/- 6.7 years). T2DM was 
      defined as self-reported T2DM or antidiabetic treatment. Stroke severity was 
      evaluated with the National Institutes of Health Stroke Scale (NIHSS) score at 
      admission. The outcome was assessed with the modified Rankin scale (mRS) score at 
      discharge and with in-hospital mortality. Adverse outcome was defined as mRS 
      score at discharge >/= 2 or in-hospital death. The length of hospitalization was 
      also recorded. RESULTS: T2DM was present in 32.2% of the study population. 
      Patients with T2DM had a larger waist circumference, higher serum triglyceride 
      and glucose levels and lower serum high-density lipoprotein cholesterol levels as 
      well as higher prevalence of hypertension, coronary heart disease and congestive 
      heart failure than patients without T2DM. On the other hand, diabetic patients 
      had lower low-density lipoprotein cholesterol levels and reported smaller 
      consumption of alcohol than non-diabetic patients. At admission, the NIHSS score 
      did not differ between patients with and without T2DM (8.7 +/- 8.8 and 8.6 +/- 9.2, 
      respectively; P = NS). At discharge, the mRS score also did not differ between 
      the two groups (2.7 +/- 2.1 and 2.7 +/- 2.2 in patients with and without T2DM, 
      respectively; P = NS). Rates of adverse outcome were also similar in patients 
      with and without T2DM (62.3% and 58.5%, respectively; P = NS). However, when we 
      adjusted for the differences between patients with T2DM and those without T2DM in 
      cardiovascular risk factors, T2DM was independently associated with adverse 
      outcome [relative risk (RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. In-hospital 
      mortality rates did not differ between patients with T2DM and those without T2DM 
      (9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the 
      difference in cardiovascular risk factors between the two groups, T2DM was again 
      not associated with in-hospital death. CONCLUSION: T2DM does not appear to affect 
      ischemic stroke severity but is independently associated with a worse functional 
      outcome at discharge.
FAU - Tziomalos, Konstantinos
AU  - Tziomalos K
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Spanou, Marianna
AU  - Spanou M
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Bouziana, Stella D
AU  - Bouziana SD
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Papadopoulou, Maria
AU  - Papadopoulou M
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Giampatzis, Vasilios
AU  - Giampatzis V
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Kostaki, Stavroula
AU  - Kostaki S
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Dourliou, Vasiliki
AU  - Dourliou V
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Tsopozidi, Maria
AU  - Tsopozidi M
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Savopoulos, Christos
AU  - Savopoulos C
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
FAU - Hatzitolios, Apostolos I
AU  - Hatzitolios AI
AD  - Konstantinos Tziomalos, Marianna Spanou, Stella D Bouziana, Maria Papadopoulou, 
      Vasilios Giampatzis, Stavroula Kostaki, Vasiliki Dourliou, Maria Tsopozidi, 
      Christos Savopoulos, Apostolos I Hatzitolios, First Propedeutic Department of 
      Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA 
      Hospital, 54636 Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC4265884
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Cardiovascular risk
OT  - Dyslipidemia
OT  - Functional outcome
OT  - Hyperglycemia
OT  - Hypertension
OT  - Ischemic stroke
OT  - Mortality
OT  - Severity
OT  - Type 2 diabetes mellitus
EDAT- 2014/12/17 06:00
MHDA- 2014/12/17 06:01
PMCR- 2014/12/15
CRDT- 2014/12/17 06:00
PHST- 2014/04/18 00:00 [received]
PHST- 2014/07/02 00:00 [revised]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/12/17 06:00 [entrez]
PHST- 2014/12/17 06:00 [pubmed]
PHST- 2014/12/17 06:01 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
AID - 10.4239/wjd.v5.i6.939 [doi]
PST - ppublish
SO  - World J Diabetes. 2014 Dec 15;5(6):939-44. doi: 10.4239/wjd.v5.i6.939.