PMID- 25515204
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 25
IP  - 6
DP  - 2015 Jun
TI  - Chest CT using spectral filtration: radiation dose, image quality, and spectrum 
      of clinical utility.
PG  - 1598-606
LID - 10.1007/s00330-014-3559-1 [doi]
AB  - OBJECTIVES: To determine the radiation dose, image quality, and clinical utility 
      of non-enhanced chest CT with spectral filtration. METHODS: We retrospectively 
      analysed 25 non-contrast chest CT examinations acquired with spectral filtration 
      (tin-filtered Sn100 kVp spectrum) compared to 25 examinations acquired without 
      spectral filtration (120 kV). Radiation metrics were compared. Image noise was 
      measured. Contrast-to-noise-ratio (CNR) and figure-of-merit (FOM) were 
      calculated. Diagnostic confidence for the assessment of various thoracic 
      pathologies was rated by two independent readers. RESULTS: Effective chest 
      diameters were comparable between groups (P = 0.613). In spectral filtration CT, 
      median CTDIvol, DLP, and size-specific dose estimate (SSDE) were reduced (0.46 
      vs. 4.3 mGy, 16 vs. 141 mGy*cm, and 0.65 vs. 5.9 mGy, all P < 0.001). Spectral 
      filtration CT had higher image noise (21.3 vs. 13.2 HU, P < 0.001) and lower CNR 
      (47.2 vs. 75.3, P < 0.001), but was more dose-efficient (FOM 10,659 vs. 
      2,231/mSv, P < 0.001). Diagnostic confidence for parenchymal lung disease and 
      osseous pathologies was lower with spectral filtration CT, but no significant 
      difference was found for pleural pathologies, pulmonary nodules, or pneumonia. 
      CONCLUSIONS: Non-contrast chest CT using spectral filtration appears to be 
      sufficient for the assessment of a considerable spectrum of thoracic pathologies, 
      while providing superior dose efficiency, allowing for substantial radiation dose 
      reduction. KEY POINTS: * Spectral filtration enables non-contrast chest CT with 
      very high dose efficiency. * This approach reduces CTDI vol , DLP, and SSDE 
      (effective chest diameter 28 cm). * Lung nodules, pneumonia, and pleural 
      pathologies can be assessed with uncompromised confidence.
FAU - Braun, Franziska M
AU  - Braun FM
AD  - Institute for Clinical Radiology, University Hospital Munich, Marchioninistrasse 
      15, 81377, Munich, Germany, franziska.braun@med.uni-muenchen.de.
FAU - Johnson, Thorsten R C
AU  - Johnson TR
FAU - Sommer, Wieland H
AU  - Sommer WH
FAU - Thierfelder, Kolja M
AU  - Thierfelder KM
FAU - Meinel, Felix G
AU  - Meinel FG
LA  - eng
PT  - Journal Article
DEP - 20141217
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Lung/diagnostic imaging
MH  - Lung Diseases/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - *Radiation Dosage
MH  - Radiographic Image Enhancement/*methods
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2014/12/18 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/18 06:00
PHST- 2014/05/15 00:00 [received]
PHST- 2014/12/05 00:00 [accepted]
PHST- 2014/11/24 00:00 [revised]
PHST- 2014/12/18 06:00 [entrez]
PHST- 2014/12/18 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s00330-014-3559-1 [doi]
PST - ppublish
SO  - Eur Radiol. 2015 Jun;25(6):1598-606. doi: 10.1007/s00330-014-3559-1. Epub 2014 
      Dec 17.