PMID- 25515578
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20220316
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 1
DP  - 2014 Dec 16
TI  - Microperimetry of nascent geographic atrophy in age-related macular degeneration.
PG  - 115-21
LID - 10.1167/iovs.14-15614 [doi]
AB  - PURPOSE: To determine the microperimetric retinal sensitivity in areas with 
      nascent geographic atrophy (nGA) compared with other pathological features in 
      eyes with intermediate AMD. METHODS: Participants with bilateral intermediate AMD 
      underwent microperimetry examinations and high-resolution spectral-domain optical 
      coherence tomography (SD-OCT) scans in a prospective study. Twenty-two 
      participants (24 eyes) identified as having a microperimetric stimulus sampling 
      an atrophic area (nGA or drusen-associated atrophy detected on SD-OCT) in an eye 
      were analyzed, using three neighboring nonatrophic regions (with or without 
      AMD-associated features) in the same eye as reference areas. RESULTS: On average, 
      the mean microperimetric retinal sensitivity was worse in areas with nGA than 
      nonatrophic reference areas (P </= 0.008), but better than areas with 
      drusen-associated atrophy (P = 0.008). Considering all the microperimetry points 
      in an eye, there were only 6 out of 16 eyes (37.5%) where the retinal sensitivity 
      over nGA was the worst performing point in the eye, while all eight out of eight 
      eyes (100.0%) with an area of drusen-associated atrophy detected on SD-OCT had 
      the worst-performing point over that area. CONCLUSIONS: Areas of nGA were 
      characterized by worse microperimetric retinal sensitivity compared with 
      nonatrophic areas in eyes with intermediate AMD, but better retinal sensitivity 
      compared with areas of drusen-associated atrophy detected on SD-OCT. Areas of nGA 
      were also not always the worst performing point in an eye. These findings further 
      our understanding of the functional changes occurring in novel SD-OCT identified 
      pathological changes in intermediate AMD.
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Wu, Zhichao
AU  - Wu Z
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Ayton, Lauren N
AU  - Ayton LN
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Luu, Chi D
AU  - Luu CD
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Guymer, Robyn H
AU  - Guymer RH
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141216
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Geographic Atrophy/*diagnosis/physiopathology
MH  - Humans
MH  - Macular Degeneration/diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Pigment Epithelium/*pathology/physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests
MH  - *Visual Fields
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - geographic atrophy
OT  - microperimetry
OT  - optical coherence tomography
EDAT- 2014/12/18 06:00
MHDA- 2015/03/11 06:00
CRDT- 2014/12/18 06:00
PHST- 2014/12/18 06:00 [entrez]
PHST- 2014/12/18 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
AID - iovs.14-15614 [pii]
AID - 10.1167/iovs.14-15614 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):115-21. doi: 10.1167/iovs.14-15614.