PMID- 2551920
OWN - NLM
STAT- MEDLINE
DCOM- 19891120
LR  - 20190510
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 4
IP  - 5
DP  - 1989 Jul
TI  - In-vivo transperitoneal fertilization.
PG  - 521-6
AB  - We present the technique of in-vivo transperitoneal fertilization (IVTPF) as a 
      first approach to infertility treatment in couples with male subfertility or 
      unexplained factors. The technique is statistically less successful but also less 
      invasive than either gamete intra-Fallopian transfer (GIFT) or in-vitro 
      fertilization - embryo transfer (IVFET) and offers considerable advantages over 
      intrauterine insemination (IUI). The IVTPF technique involves transperitoneal 
      transfer of processed spermatozoa within the pouch of Douglas after induction of 
      ovulation. We report our 4-year experience with IVTPF which includes 136 
      treatment cycles in 89 couples. Eight pregnancies were achieved in 89 patients 
      (9%) and 136 treatment cycles (7%). Fifty-one patients (57%) received IVTPF for 
      only one treatment cycle; seven of the eight IVTPF pregnancies occurred in this 
      group. An ectopic pregnancy resulted in one of the eight IVTPF pregnancies (13%). 
      The functional quality of the sperm in those couples who achieved pregnancy was 
      statistically superior to those couples who did not conceive. However, pregnancy 
      was also obtained in case of severe oligozoospermia. Based on our experience, we 
      feel IVTPF to be a very reasonable first approach in patients with no pelvic 
      pathology and with infertility secondary to male factors or unexplained causes.
FAU - Lesec, G
AU  - Lesec G
AD  - Groupe Fecondation Artificielle Mediate, Polyclinique La Pergola, Vichy, France.
FAU - Manhes, H
AU  - Manhes H
FAU - Hardy, R I
AU  - Hardy RI
FAU - Richard, E
AU  - Richard E
FAU - Force, A
AU  - Force A
FAU - Dejardin, F
AU  - Dejardin F
FAU - De Montmarin, J L
AU  - De Montmarin JL
FAU - Gilbert-Jeantet, P
AU  - Gilbert-Jeantet P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Ubiquitins)
RN  - 1HRS458QU2 (Clomiphene)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adult
MH  - Chorionic Gonadotropin/therapeutic use
MH  - Clomiphene/therapeutic use
MH  - Female
MH  - *Fertilization
MH  - Humans
MH  - Infertility, Male
MH  - Male
MH  - Middle Aged
MH  - Oogenesis/drug effects
MH  - *Peritoneum
MH  - Progesterone/therapeutic use
MH  - Sperm Count
MH  - Sperm Motility
MH  - Ubiquitins/therapeutic use
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.humrep.a136937 [doi]
PST - ppublish
SO  - Hum Reprod. 1989 Jul;4(5):521-6. doi: 10.1093/oxfordjournals.humrep.a136937.