PMID- 25519813
OWN - NLM
STAT- MEDLINE
DCOM- 20160226
LR  - 20181113
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 12
DP  - 2014 Dec 18
TI  - Dendritic cells during Staphylococcus aureus infection: subsets and roles.
PG  - 358
LID - 10.1186/s12967-014-0358-z [doi]
LID - 358
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play 
      a crucial role in both innate and adaptive immune responses. DCs orient the 
      immune responses by modulating the balance between protective immunity to 
      pathogens and tolerance to self-antigens. Staphylococcus aureus (S. aureus) is a 
      common member of human skin microbiota and can cause severe infections with 
      significant morbidity and mortality. Protective immunity to pathogens by DCs is 
      required for clearance of S. aureus. DCs sense the presence of the staphylococcal 
      components using pattern recognition receptors (PRRs) and then orchestrate immune 
      systems to resolve infections. This review summarizes the possible roles of DCs, 
      in particular their Toll-like receptors (TLRs) involved in S. aureus infection 
      and strategies by which the pathogen affects activation and function of DCs.
FAU - Wu, Xuejie
AU  - Wu X
AD  - Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310009, China. wuxuejie81@163.com.
FAU - Xu, Feng
AU  - Xu F
AD  - Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, 310009, China. xufeng99@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141218
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lymphocyte Subsets
MH  - Staphylococcal Infections/*immunology
MH  - Staphylococcus aureus/*immunology/pathogenicity
MH  - Toll-Like Receptors/immunology
MH  - Virulence
PMC - PMC4279898
EDAT- 2014/12/19 06:00
MHDA- 2016/02/27 06:00
PMCR- 2014/12/18
CRDT- 2014/12/19 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2014/12/10 00:00 [accepted]
PHST- 2014/12/19 06:00 [entrez]
PHST- 2014/12/19 06:00 [pubmed]
PHST- 2016/02/27 06:00 [medline]
PHST- 2014/12/18 00:00 [pmc-release]
AID - s12967-014-0358-z [pii]
AID - 358 [pii]
AID - 10.1186/s12967-014-0358-z [doi]
PST - epublish
SO  - J Transl Med. 2014 Dec 18;12:358. doi: 10.1186/s12967-014-0358-z.