PMID- 25520003
OWN - NLM
STAT- MEDLINE
DCOM- 20161007
LR  - 20181113
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 1
DP  - 2016 Jan
TI  - Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion 
      Volumes.
PG  - 677-685
LID - 10.1007/s12035-014-9016-y [doi]
AB  - Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein 
      with antioxidant activity recognized as an oxidative stress marker. The aim of 
      this study was to assess the clinical significance of serum TRX levels in Chinese 
      patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 
      2013, all patients with first-ever acute ischemic stroke were recruited to 
      participate in the study. Serum levels of TRX were assayed with solid-phase 
      sandwich enzyme-linked immunosorbent assay (ELISA), and the severity of stroke 
      was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score 
      on admission. The results indicated that the median serum TRX levels were 
      significantly (P < 0.0001) higher in stroke patients as compared to normal cases 
      [15.03 ng/mL (interquartile range (IQR), 10.21-32.42) and 8.95 ng/mL 
      (6.79-11.05), respectively]. We found the serum TRX reflected the disease 
      severity of AIS. There was a significant positive association between serum TRX 
      levels and NIHSS scores (r = 0.476, P < 0.0001). After adjusting for all other 
      possible covariates, TRX remained as an independent marker of AIS with an 
      adjusted OR of 1.245 (95 % confidence interval (CI), 1.164-1.352; P < 0.0001). 
      Based on the receiver operating characteristic (ROC) curve, the optimal cutoff 
      value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was 
      projected to be 11.0 ng/mL, which yielded a sensitivity of 80.3 % and a 
      specificity of 73.7 %, with the area under the curve at 0.807 (95 % CI, 
      0.766-0.847). Further, in our study, we found that an increased risk of AIS was 
      associated with serum TRX levels >/=11.0 ng/mL (adjusted OR 6.99; 95 % CI, 
      2.87-12.87) after adjusting for possible confounders. Our study demonstrated that 
      serum TRX levels at admission were associated with stroke severity and lesion 
      volumes. Elevated levels could be considered as a novel, independent diagnosis 
      marker of AIS in a Chinese sample.
FAU - Wu, Meng-Hai
AU  - Wu MH
AD  - Department of Neurology, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China.
FAU - Song, Fang-Yu
AU  - Song FY
AD  - Department of Neurology, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China.
FAU - Wei, Li-Ping
AU  - Wei LP
AD  - Department of Neurology, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China.
FAU - Meng, Zhao-Yun
AU  - Meng ZY
AD  - Special Procurement Ward, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China.
FAU - Zhang, Zhi-Qiang
AU  - Zhang ZQ
AD  - Department of Cardiology, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China. luxxyy796@163.com.
FAU - Qi, Qin-De
AU  - Qi QD
AD  - Department of Neurology, Laiwu People's Hospital, No. 1, Xuehudajie, Changshao 
      North Road, Laiwu, 271100, Shandong Province, China. qiqde634@126.com.
LA  - eng
PT  - Journal Article
DEP - 20141219
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Biomarkers)
RN  - 52500-60-4 (Thioredoxins)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - *Severity of Illness Index
MH  - Stroke/*blood/*diagnosis
MH  - Thioredoxins/*blood
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - Chinese
OT  - Oxidative stress
OT  - Risk
OT  - Thioredoxin
EDAT- 2014/12/19 06:00
MHDA- 2016/10/08 06:00
CRDT- 2014/12/19 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2014/12/19 06:00 [entrez]
PHST- 2014/12/19 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
AID - 10.1007/s12035-014-9016-y [pii]
AID - 10.1007/s12035-014-9016-y [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Jan;53(1):677-685. doi: 10.1007/s12035-014-9016-y. Epub 2014 
      Dec 19.