PMID- 25520955
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141218
LR  - 20181113
IS  - 2332-7812 (Print)
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 1
IP  - 4
DP  - 2014 Dec
TI  - Natalizumab-related anaphylactoid reactions in MS patients are associated with 
      HLA class II alleles.
PG  - e47
LID - 10.1212/NXI.0000000000000047 [doi]
LID - e47
AB  - OBJECTIVES: We aimed to investigate potential associations between human 
      leukocyte antigen (HLA) class I and class II alleles and the development of 
      anaphylactic/anaphylactoid reactions in patients with multiple sclerosis (MS) 
      treated with natalizumab. METHODS: HLA class I and II genotyping was performed in 
      patients with MS who experienced anaphylactic/anaphylactoid reactions and in 
      patients who did not develop infusion-related allergic reactions following 
      natalizumab administration. RESULTS: A total of 119 patients with MS from 3 
      different cohorts were included in the study: 54 with natalizumab-related 
      anaphylactic/anaphylactoid reactions and 65 without allergic reactions. 
      HLA-DRB1*13 and HLA-DRB1*14 alleles were significantly increased in patients who 
      developed anaphylactic/anaphylactoid reactions (p M-H = 3 x 10(-7); odds ratio 
      [OR]M-H = 8.96, 95% confidence interval [CI] = 3.40-23.64), with a positive 
      predictive value (PPV) of 82%. In contrast, the HLA-DRB1*15 allele was 
      significantly more represented in patients who did not develop 
      anaphylactic/anaphylactoid reactions to natalizumab (p M-H = 6 x 10(-4); ORM-H = 
      0.2, 95% CI = 0.08-0.50), with a PPV of 81%. CONCLUSIONS: HLA-DRB1 genotyping 
      before natalizumab treatment may help neurologists to identify patients with MS 
      at risk for developing serious systemic hypersensitivity reactions associated 
      with natalizumab administration.
FAU - de la Hera, Belen
AU  - de la Hera B
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Urcelay, Elena
AU  - Urcelay E
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Brassat, David
AU  - Brassat D
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Chan, Andrew
AU  - Chan A
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Vidal-Jordana, Angela
AU  - Vidal-Jordana A
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Salmen, Anke
AU  - Salmen A
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Villar, Luisa Maria
AU  - Villar LM
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Alvarez-Cermeno, Jose Carlos
AU  - Alvarez-Cermeno JC
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Izquierdo, Guillermo
AU  - Izquierdo G
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Fernandez, Oscar
AU  - Fernandez O
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Oliver, Begona
AU  - Oliver B
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Saiz, Albert
AU  - Saiz A
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Ara, Jose Ramon
AU  - Ara JR
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Vigo, Ana G
AU  - Vigo AG
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Arroyo, Rafael
AU  - Arroyo R
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Meca, Virginia
AU  - Meca V
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Malhotra, Sunny
AU  - Malhotra S
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Fissolo, Nicolas
AU  - Fissolo N
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Horga, Alejandro
AU  - Horga A
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Montalban, Xavier
AU  - Montalban X
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
FAU - Comabella, Manuel
AU  - Comabella M
AD  - Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, 
      Multiple Sclerosis Unit (R.A.), Hospital Clinico San Carlos (IdISSC), Madrid, 
      Spain; Pole des neurosciences et INSERM U1043 (D.B.), Universite de Toulouse III, 
      Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. 
      Josef-Hospital, Ruhr University, Bochum, Germany; Servei de 
      Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre 
      d'Esclerosi Multiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron 
      (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 
      Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital 
      Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria, 
      Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; 
      Unidad de Gestion Clinica de Neurociencias (O.F., B.O.), Instituto de Biomedicina 
      de Malaga (IBIMA), Hospital Universitario Regional de Malaga, Universidad de 
      Malaga, Spain; Service of Neurology (A. Saiz), Hospital Clinic, Universitat de 
      Barcelona and Institut d Investigacio Biomedica August Pi i Sunyer (IDIBAPS), 
      Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology 
      (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundacion de 
      Investigacion Biomedica (V.M.), Hospital Universitario de la Princesa, Madrid, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20141211
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
PMC - PMC4268037
EDAT- 2014/12/19 06:00
MHDA- 2014/12/19 06:01
PMCR- 2014/12/11
CRDT- 2014/12/19 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2014/12/19 06:00 [entrez]
PHST- 2014/12/19 06:00 [pubmed]
PHST- 2014/12/19 06:01 [medline]
PHST- 2014/12/11 00:00 [pmc-release]
AID - NEURIMMINFL2014002105 [pii]
AID - 10.1212/NXI.0000000000000047 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2014 Dec 11;1(4):e47. doi: 
      10.1212/NXI.0000000000000047. eCollection 2014 Dec.