PMID- 25522244
OWN - NLM
STAT- MEDLINE
DCOM- 20151221
LR  - 20240325
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 8
IP  - 12
DP  - 2014 Dec
TI  - Comparison of safety and immunogenicity of PVRV and PCECV immunized in patients 
      with WHO category II animal exposure: a study based on different age groups.
PG  - e3412
LID - 10.1371/journal.pntd.0003412 [doi]
LID - e3412
AB  - BACKGROUND: The aim of this study was to compare the safety and immunogenicity 
      between purified vero cell rabies vaccine (PVRV) and purified chick embryo cell 
      vaccine (PCECV) in patients with WHO category II animal exposure, especially in 
      different age groups. METHODOLOGY/PRINCIPAL FINDINGS: In one-year clinical 
      observation after vaccination with PVRV or PCECV under Zagreb (2-1-1) or Essen 
      (1-1-1-1-1) regimens, information collection for the demographic and adverse 
      events (AEs) and rabies virus laboratory examination of neutralizing antibody 
      (RVNA) titers were performed for all patients with WHO category II animal 
      exposure in Wuhan city. The results showed no significant differences of safety 
      and immunogenicity between PVRV and PCECV both in Zagreb and Essen regimens. 
      However, when compared with other age groups, most systemic AEs (36/61) occurred 
      in <5-year-old patients, and <5-year-old patients have significant lower RVNA 
      titer and seroconversion rate (RVNA >/=0.5 IU/ml) at day 7 both in Zagreb and Essen 
      regimens or PVRV and PCECV groups. CONCLUSIONS: Our data showed that vaccination 
      with PVRV is as safe and immunogenic as PCECV in patients of all age groups, but 
      might be more popular for clinical use. When performing a vaccination with rabies 
      vaccine in young children, the most optimal vaccine regimen should be selected.
FAU - Fang, Yuan
AU  - Fang Y
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Chen, Li
AU  - Chen L
AD  - Jianghan District Centers for Disease Control and Prevention, Wuhan, China.
FAU - Liu, Man-Qing
AU  - Liu MQ
AD  - Wuhan Centers for Disease Control and Prevention, Wuhan, China.
FAU - Zhu, Zheng-Gang
AU  - Zhu ZG
AD  - Wuhan Centers for Disease Control and Prevention, Wuhan, China.
FAU - Zhu, Ze-Rong
AU  - Zhu ZR
AD  - Wuhan Centers for Disease Control and Prevention, Wuhan, China.
FAU - Hu, Quan
AU  - Hu Q
AD  - Wuhan Centers for Disease Control and Prevention, Wuhan, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20141218
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Antibodies, Viral)
RN  - 0 (Rabies Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Chick Embryo
MH  - Child
MH  - Child, Preschool
MH  - Chlorocebus aethiops
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Post-Exposure Prophylaxis
MH  - Rabies/*prevention & control
MH  - Rabies Vaccines/adverse effects/*immunology
MH  - Vaccination
MH  - Vero Cells
PMC - PMC4270726
COIS- The authors have declared that no competing interests exist.
EDAT- 2014/12/19 06:00
MHDA- 2015/12/22 06:00
PMCR- 2014/12/18
CRDT- 2014/12/19 06:00
PHST- 2014/06/20 00:00 [received]
PHST- 2014/11/12 00:00 [accepted]
PHST- 2014/12/19 06:00 [entrez]
PHST- 2014/12/19 06:00 [pubmed]
PHST- 2015/12/22 06:00 [medline]
PHST- 2014/12/18 00:00 [pmc-release]
AID - PNTD-D-14-01045 [pii]
AID - 10.1371/journal.pntd.0003412 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3412. doi: 10.1371/journal.pntd.0003412. 
      eCollection 2014 Dec.