PMID- 25522421
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20240322
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 18
IP  - 5
DP  - 2014 Dec 7
TI  - Temporal regulation of peripheral BDNF levels during cocaine and morphine 
      withdrawal: comparison with a natural reward.
LID - pyu088 [pii]
LID - 10.1093/ijnp/pyu088 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has 
      long been studied in the field of addiction and its importance in regulating drug 
      addiction-related behavior has been widely demonstrated. The aim of our study was 
      to analyze the consequences of a repeated exposure to drugs of abuse or natural 
      reward on plasma BDNF levels during withdrawal. METHODS: Rats were chronically 
      injected with morphine (subcutaneously, 5mg/kg) or cocaine (intraperitoneally, 
      20mg/kg) or fed with a butter biscuit (per os, 4g) once per day for 14 days. 
      Blood collection was performed on the 1st (withdrawal day 1 or WD1) or on (WD14), 
      either at the same time point rats had been exposed to drugs or natural reward or 
      at a different time point (used to quantify basal brain-derived neurotrophic 
      factor levels). RESULTS: Cocaine treatment led to a rapid (WD1) and persistent 
      (WD14) decrease of basal BDNF levels compared with saline-treated animals, 
      whereas morphine induced an increase on WD14 without any alteration on WD1. On 
      the contrary, the natural reward induced a significant increase of basal 
      brain-derived neurotrophic factor levels only on WD1. The analysis of BDNF levels 
      at the usual time point at which animals had been exposed showed that both drugs, 
      but not the natural reward, increased BDNF levels compared with basal levels. 
      CONCLUSION: Our data highlight that only drugs of abuse are able to persistently 
      alter BDNF levels and to induce specific variations of this neurotrophic factor 
      at the usual hour of injection.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of CINP.
FAU - Geoffroy, Helene Anne-Sophie
AU  - Geoffroy HA
AD  - Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and 
      Noble); Institut National de la Sante et de la Recherche Medicale, France (Ms 
      Geoffroy, Drs Puig, Benturquia, and Noble); Universite Paris Descartes, Paris, 
      France (Ms Geoffroy, Drs Puig, Benturquia, and Noble).
FAU - Puig, Stephanie
AU  - Puig S
AD  - Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and 
      Noble); Institut National de la Sante et de la Recherche Medicale, France (Ms 
      Geoffroy, Drs Puig, Benturquia, and Noble); Universite Paris Descartes, Paris, 
      France (Ms Geoffroy, Drs Puig, Benturquia, and Noble).
FAU - Benturquia, Nadia
AU  - Benturquia N
AD  - Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and 
      Noble); Institut National de la Sante et de la Recherche Medicale, France (Ms 
      Geoffroy, Drs Puig, Benturquia, and Noble); Universite Paris Descartes, Paris, 
      France (Ms Geoffroy, Drs Puig, Benturquia, and Noble).
FAU - Noble, Florence
AU  - Noble F
AD  - Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and 
      Noble); Institut National de la Sante et de la Recherche Medicale, France (Ms 
      Geoffroy, Drs Puig, Benturquia, and Noble); Universite Paris Descartes, Paris, 
      France (Ms Geoffroy, Drs Puig, Benturquia, and Noble). 
      florence.noble@parisdescartes.fr.
LA  - eng
PT  - Journal Article
DEP - 20141207
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 76I7G6D29C (Morphine)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Male
MH  - Morphine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Reward
MH  - Substance Withdrawal Syndrome
PMC - PMC4376544
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - cocaine
OT  - morphine
OT  - natural reward
OT  - plasma
EDAT- 2014/12/19 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/01/28
CRDT- 2014/12/19 06:00
PHST- 2014/12/19 06:00 [entrez]
PHST- 2014/12/19 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/01/28 00:00 [pmc-release]
AID - pyu088 [pii]
AID - 10.1093/ijnp/pyu088 [doi]
PST - epublish
SO  - Int J Neuropsychopharmacol. 2014 Dec 7;18(5):pyu088. doi: 10.1093/ijnp/pyu088.