PMID- 25522665
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20211203
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 36
IP  - 1
DP  - 2015 Jan
TI  - Regulation of T cells by mTOR: the known knowns and the known unknowns.
PG  - 13-20
LID - S1471-4906(14)00209-9 [pii]
LID - 10.1016/j.it.2014.11.005 [doi]
AB  - Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important 
      integrator of environmental cues critical for the regulation of T cell 
      activation, differentiation, and function. Recent studies leveraging 
      pharmacologic inhibition or T cell specific genetic deletion of signaling 
      components in the mTOR pathway have provided important insights into the 
      mechanisms involved, and have been informative in defining targets downstream of 
      mTOR that promote immune regulation. However, these studies have also presented 
      confusing and, at times, contradictory findings, highlighting the complexities 
      involved in examining the mTOR pathway in distinct contexts. Here, we review 
      current understanding of the roles of mTOR in T cell biology, highlighting 
      emerging concepts and areas of investigation where the precise role of mTOR has 
      yet to be fully discerned.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Pollizzi, Kristen N
AU  - Pollizzi KN
AD  - Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins 
      University School of Medicine, Baltimore, MD 21287, USA. Electronic address: 
      kpolliz2@jhmi.edu.
FAU - Powell, Jonathan D
AU  - Powell JD
AD  - Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins 
      University School of Medicine, Baltimore, MD 21287, USA. Electronic address: 
      poweljo@jhmi.edu.
LA  - eng
GR  - R01AI077610/AI/NIAID NIH HHS/United States
GR  - R01 AI091481/AI/NIAID NIH HHS/United States
GR  - T32 AI007247/AI/NIAID NIH HHS/United States
GR  - R01AI091481/AI/NIAID NIH HHS/United States
GR  - R01 AI077610/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20141216
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/cytology/immunology/metabolism
MH  - Cell Differentiation/genetics/immunology
MH  - Gene Deletion
MH  - Humans
MH  - Lymphocyte Activation/genetics/immunology
MH  - Signal Transduction
MH  - T-Lymphocytes/cytology/*immunology/*metabolism
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
PMC - PMC4290883
MID - NIHMS650375
OTO - NOTNLM
OT  - T cells
OT  - mTOR
OT  - rapamycin
EDAT- 2014/12/20 06:00
MHDA- 2015/09/17 06:00
PMCR- 2016/01/01
CRDT- 2014/12/20 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2014/11/18 00:00 [revised]
PHST- 2014/11/19 00:00 [accepted]
PHST- 2014/12/20 06:00 [entrez]
PHST- 2014/12/20 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - S1471-4906(14)00209-9 [pii]
AID - 10.1016/j.it.2014.11.005 [doi]
PST - ppublish
SO  - Trends Immunol. 2015 Jan;36(1):13-20. doi: 10.1016/j.it.2014.11.005. Epub 2014 
      Dec 16.