PMID- 25522990
OWN - NLM
STAT- MEDLINE
DCOM- 20150415
LR  - 20181202
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 224
DP  - 2015
TI  - Signal transduction by HDL: agonists, receptors, and signaling cascades.
PG  - 229-56
LID - 10.1007/978-3-319-09665-0_6 [doi]
AB  - Numerous epidemiologic studies revealed that high-density lipoprotein (HDL) is an 
      important risk factor for coronary heart disease. There are several 
      well-documented HDL functions such as reversed cholesterol transport, inhibition 
      of inflammation, or inhibition of platelet activation that may account for the 
      atheroprotective effects of this lipoprotein. Mechanistically, these functions 
      are carried out by a direct interaction of HDL particle or its components with 
      receptors localized on the cell surface followed by generation of intracellular 
      signals. Several HDL-associated receptor ligands such as apolipoprotein A-I 
      (apoA-I) or sphingosine-1-phosphate (S1P) have been identified in addition to HDL 
      holoparticles, which interact with surface receptors such as ATP-binding cassette 
      transporter A1 (ABCA1); S1P receptor types 1, 2, and 3 (S1P1, S1P2, and S1P3); or 
      scavenger receptor type I (SR-BI) and activate intracellular signaling cascades 
      encompassing kinases, phospholipases, trimeric and small G-proteins, and 
      cytoskeletal proteins such as actin or junctional protein such as connexin43. In 
      addition, depletion of plasma cell cholesterol mediated by ABCA1, ATP-binding 
      cassette transporter G1 (ABCG1), or SR-BI was demonstrated to indirectly inhibit 
      signaling over proinflammatory or proliferation-stimulating receptors such as 
      Toll-like or growth factor receptors. The present review summarizes the current 
      knowledge regarding the HDL-induced signal transduction and its relevance to 
      athero- and cardioprotective effects as well as other physiological effects 
      exerted by HDL.
FAU - Nofer, Jerzy-Roch
AU  - Nofer JR
AD  - Center for Laboratory Medicine, University Hospital Munster, 
      Albert-Schweizer-Campus 1, Geb. A1, D-48149, Munster, Germany, 
      nofer@uni-muenster.de.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ABCG1 protein, human)
RN  - 0 (APOA1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Ligands)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lysophospholipids)
RN  - 0 (P2RY12 protein, human)
RN  - 0 (P2RY13 protein, human)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Purinergic P2)
RN  - 0 (Receptors, Purinergic P2Y12)
RN  - 0 (SCARB1 protein, human)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (high density lipoprotein receptors)
RN  - 26993-30-6 (sphingosine 1-phosphate)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Adenosine Triphosphatases/metabolism
MH  - Animals
MH  - Apolipoprotein A-I/metabolism
MH  - Arteries/*metabolism/pathology
MH  - Atherosclerosis/metabolism/pathology
MH  - Humans
MH  - Ligands
MH  - Lipoproteins, HDL/agonists/blood/*metabolism
MH  - Lysophospholipids/metabolism
MH  - Receptors, Lipoprotein/*metabolism
MH  - Receptors, Purinergic P2/metabolism
MH  - Receptors, Purinergic P2Y12/metabolism
MH  - Scavenger Receptors, Class B/metabolism
MH  - *Signal Transduction
MH  - Sphingosine/analogs & derivatives/metabolism
EDAT- 2014/12/20 06:00
MHDA- 2015/04/16 06:00
CRDT- 2014/12/20 06:00
PHST- 2014/12/20 06:00 [entrez]
PHST- 2014/12/20 06:00 [pubmed]
PHST- 2015/04/16 06:00 [medline]
AID - 10.1007/978-3-319-09665-0_6 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2015;224:229-56. doi: 10.1007/978-3-319-09665-0_6.