PMID- 25523296
OWN - NLM
STAT- MEDLINE
DCOM- 20160309
LR  - 20150613
IS  - 1941-7225 (Electronic)
IS  - 0895-7061 (Linking)
VI  - 28
IP  - 7
DP  - 2015 Jul
TI  - Association Between Arterial Stiffness and Skin Microvascular Function: The 
      SUVIMAX2 Study and The Maastricht Study.
PG  - 868-76
LID - 10.1093/ajh/hpu246 [doi]
AB  - BACKGROUND: It has been hypothesized that arterial stiffness leads to generalized 
      microvascular dysfunction and that individuals with type 2 diabetes mellitus 
      (T2DM) are particularly prone to the detrimental effects of arterial stiffness. 
      However, evidence for an association between stiffness and markers of generalized 
      microvascular dysfunction is lacking. We therefore investigated the association 
      between arterial stiffness and skin microvascular function in individuals without 
      and with T2DM. METHODS: Cross-sectional data were used of The Supplementation en 
      Vitamines et Mineraux Antioxydants 2 (SUVIMAX2) Study (n = 284/62.2 years/48.6% 
      women/0% T2DM (by design)) and The Maastricht Study (n = 737/59.7 years/45.2% 
      women/28.8% T2DM (by design)). Arterial stiffness was determined by 
      carotid-femoral pulse wave velocity (cfPWV). Skin capillaroscopy was used to 
      determine capillary density at baseline, and during reactive hyperemia and venous 
      congestion. Laser Doppler flowmetry was used to assess acetylcholine- and local 
      heating-induced vasoreactivity, and skin flowmotion. RESULTS: In The SUVIMAX2 
      Study, cfPWV (per +1 SD) was not associated with baseline capillary density 
      (regression coefficient: -0.48 (95% confidence interval: 2.37; 1.41)) or 
      capillary recruitment during venous congestion (0.54% (-0.74; 1.81%)). In 
      addition, cfPWV was not associated with acetylcholine (-0.02% (-0.14; 0.10%)) or 
      local heating-induced vasoreactivity (0.03% (-0.07; 0.12%)). In The Maastricht 
      Study, in individuals without T2DM, cfPWV was not associated with baseline 
      capillary density (-1.20 (-3.17; 0.77)), and capillary recruitment during 
      reactive hyperemia (1.22% (-0.41; 2.84%)) or venous congestion (1.50% (-0.25; 
      3.25%)). In addition, cfPWV was not associated with flowmotion (-0.01 (-0.07; 
      0.06)). Results were adjusted for age and sex. Additional adjustments for 
      confounders did not materially change these results. Results were qualitatively 
      similar in individuals with T2DM. CONCLUSIONS: Arterial stiffness is not 
      associated with skin microvascular function, irrespective of the presence of 
      T2DM.
CI  - (c) American Journal of Hypertension, Ltd 2014. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - van Sloten, Thomas T
AU  - van Sloten TT
FAU - Czernichow, Sebastien
AU  - Czernichow S
FAU - Houben, Alfons J
AU  - Houben AJ
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Protogerou, Athanase D
AU  - Protogerou AD
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Henry, Ronald M
AU  - Henry RM
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Muris, Dennis M
AU  - Muris DM
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Schram, Miranda T
AU  - Schram MT
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Sep, Simone J
AU  - Sep SJ
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Dagnelie, Pieter C
AU  - Dagnelie PC
AD  - Cardiovascular Research Institute Maastricht (CARIM), Maastricht University 
      Medical Centre, Maastricht, The Netherlands; School for Public Health and Primary 
      Care (CAPHRI), Maastricht University Medical Centre, Maastricht, The Netherlands; 
      Department of Epidemiology, Maastricht University Medical Centre, Maastricht, The 
      Netherlands;
FAU - van der Kallen, Carla J
AU  - van der Kallen CJ
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands;
FAU - Schaper, Nicolaas C
AU  - Schaper NC
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands; School for Public Health 
      and Primary Care (CAPHRI), Maastricht University Medical Centre, Maastricht, The 
      Netherlands;
FAU - Blacher, Jacques
AU  - Blacher J
AD  - Diagnosis and Therapeutic Center, Hotel-Dieu Hospital, AP-HP, Paris Descartes 
      University, Paris, France;
FAU - Hercberg, Serge
AU  - Hercberg S
AD  - Nutritional Epidemiology Research Group, Sorbonne-Paris-Cite, UMR University of 
      Paris 13/INSERM U557/INRA U1125/CNAM, Bobigny, France.
FAU - Levy, Bernard I
AU  - Levy BI
AD  - INSERM, UMS 011 Population-based cohorts, Villejuif, France;
FAU - Stehouwer, Coen D
AU  - Stehouwer CD
AD  - Department of Medicine, Maastricht University Medical Centre, Maastricht, The 
      Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht 
      University Medical Centre, Maastricht, The Netherlands; cda.stehouwer@mumc.nl.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141217
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Vasodilator Agents)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Adult
MH  - Aged
MH  - Blood Flow Velocity
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/physiopathology
MH  - Diabetic Angiopathies/diagnosis/*etiology/physiopathology
MH  - Female
MH  - France
MH  - Humans
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - *Microcirculation/drug effects
MH  - Microscopic Angioscopy
MH  - Microvessels/drug effects/*physiopathology
MH  - Middle Aged
MH  - Netherlands
MH  - Prospective Studies
MH  - Pulse Wave Analysis
MH  - Regional Blood Flow
MH  - Skin/*blood supply
MH  - Skin Temperature
MH  - *Vascular Stiffness
MH  - Vasodilation
MH  - Vasodilator Agents/pharmacology
OTO - NOTNLM
OT  - blood pressure
OT  - epidemiology
OT  - hypertension
OT  - microcirculation
OT  - type 2 diabetes mellitus
OT  - vascular stiffness.
EDAT- 2014/12/20 06:00
MHDA- 2016/03/10 06:00
CRDT- 2014/12/20 06:00
PHST- 2014/09/07 00:00 [received]
PHST- 2014/11/07 00:00 [accepted]
PHST- 2014/12/20 06:00 [entrez]
PHST- 2014/12/20 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - hpu246 [pii]
AID - 10.1093/ajh/hpu246 [doi]
PST - ppublish
SO  - Am J Hypertens. 2015 Jul;28(7):868-76. doi: 10.1093/ajh/hpu246. Epub 2014 Dec 17.