PMID- 2552340
OWN - NLM
STAT- MEDLINE
DCOM- 19891102
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 50
IP  - 3
DP  - 1989 Sep
TI  - Modulation of the neonatal pituitary and adrenocortical responses to stress by 
      thyroid hormones in the rat: effects of hypothyroidism and hyperthyroidism.
PG  - 265-73
AB  - Neonatal rats exhibit a period of diminished pituitary and adrenocortical 
      responses to stress during the first 2 weeks of life. Since thyroid hormones are 
      known to affect brain development, modulation of these responses to stress by 
      alterations in thyroid hormone status have been investigated in hypothyroid 
      (Hypo) and hyperthyroid (Hyper) rat pups. Changes in ACTH and corticosterone (B) 
      levels were measured under basal and stress conditions (3 min exposure to ether 
      vapors) in neonates of various ages (day 5-21). Basal T4 and 
      corticosterone-binding globulin (CBG) levels were also measured. Hypo pups were 
      obtained from methimazole-treated mothers and hyperthyroidism was induced by 
      daily subcutaneous injections of L-T4 (100 micrograms/kg BW) from birth on. In 
      Hyper rats, premature onset of ACTH and B responses to stress was observed in 
      5-day-old rats while significant ACTH and B secretion only appeared by day 10 in 
      vehicle-injected rats. By contrast, ACTH and B responses to stress were delayed 
      in Hypo pups and only occurred by day 21. The lack of ACTH and B responses to 
      stress of 14-day-old Hypo rats could be reversed by one single L-T4 injection 
      (100 micrograms/kg BW) given 24 h, but not 4 h prior to exposure to stress. On 
      day 21, smaller (p less than 0.05) stress-induced ACTH release was observed both 
      in Hypo and Hyper rats compared to intact rats, concomitant with a diminished 
      ACTH secretion following exogenous ovine CRF (10 micrograms/kg BW, i.p.) 
      administration.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Walker, C D
AU  - Walker CD
AD  - Department of Pediatrics and Genetics, University of Geneva School of Medicine, 
      Switzerland.
FAU - Sizonenko, P C
AU  - Sizonenko PC
FAU - Aubert, M L
AU  - Aubert ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Thyroid Hormones)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9010-38-2 (Transcortin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - Q51BO43MG4 (Thyroxine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Cortex/*physiopathology
MH  - Adrenocorticotropic Hormone/metabolism
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Body Weight
MH  - Corticosterone/metabolism
MH  - Corticotropin-Releasing Hormone/pharmacology
MH  - Hyperthyroidism/physiopathology
MH  - Hypothyroidism/physiopathology
MH  - Pituitary Gland/drug effects/*physiopathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stress, Physiological/*physiopathology
MH  - Thyroid Hormones/*physiology
MH  - Thyroxine/blood/pharmacology
MH  - Transcortin/metabolism
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1159/000125232 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1989 Sep;50(3):265-73. doi: 10.1159/000125232.