PMID- 25524411
OWN - NLM
STAT- MEDLINE
DCOM- 20150810
LR  - 20150110
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 587
DP  - 2015 Feb 5
TI  - Migraine is associated with altered levels of neurotrophins.
PG  - 6-10
LID - S0304-3940(14)00958-6 [pii]
LID - 10.1016/j.neulet.2014.12.022 [doi]
AB  - Neurotrophic factors have been implicated in hyperalgesia and peripheral levels 
      of these molecules were altered in behavioral and neurological disorders. The 
      objectives of this study were to assess neurotrophic factors levels in migraine 
      patients in comparison with controls, and to investigate whether there was any 
      association between them and clinical parameters. This was a cross-sectional 
      study. We measured serum levels of neurotrophin family members - nerve growth 
      factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and 4/5 
      (NT3 and NT4/5) - and glial cell line-derived factor (GDNF) in patients suffering 
      from migraine and matched controls. One hundred forty-one people were enrolled in 
      this study, seventy-one were migraine patients and seventy were controls. 
      Migraine patients showed more depressive and anxiety symptoms than control 
      individuals as assessed, respectively, by the Beck Depression Inventory (BDI) and 
      the Beck Anxiety Inventory. Chronic and episodic migraine patients showed higher 
      NT4/5 levels than control individuals (P=0.001). Patients with chronic migraine 
      had lower levels of BDNF that were not influenced by the presence of depressive 
      symptoms (P=0.02). This is the first report to evaluate NT3 and NT-4/5 levels in 
      migraine patients. Our findings suggest a possible role of neurotrophic factors 
      in migraine pathophysiology.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Martins, Lais B
AU  - Martins LB
AD  - Nursing School, Department of Nutrition, Universidade Federal de Minas Gerais, 
      Belo Horizonte, MG, Brazil. Electronic address: laisbmnutri@gmail.com.
FAU - Duarte, Halina
AU  - Duarte H
AD  - Neuroscience Program, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 
      Brazil. Electronic address: halinaduarte@yahoo.com.
FAU - Ferreira, Adaliene V M
AU  - Ferreira AV
AD  - Nursing School, Department of Nutrition, Universidade Federal de Minas Gerais, 
      Belo Horizonte, MG, Brazil. Electronic address: adaliene@gmail.com.
FAU - Rocha, Natalia P
AU  - Rocha NP
AD  - Interdisciplinary Laboratory of Medical Investigation, School of Medicine, 
      Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic 
      address: npessoarocha@gmail.com.
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
AD  - Neuroscience Program, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 
      Brazil; Interdisciplinary Laboratory of Medical Investigation, School of 
      Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. 
      Electronic address: altexr@gmail.com.
FAU - Domingues, Renan B
AU  - Domingues RB
AD  - Neuroscience Program, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 
      Brazil. Electronic address: contato@renandomingues.med.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141215
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*blood
MH  - Nerve Growth Factors/*blood
OTO - NOTNLM
OT  - BDNF
OT  - Migraine
OT  - NT-4/5
OT  - Neurotrophic factors
EDAT- 2014/12/20 06:00
MHDA- 2015/08/11 06:00
CRDT- 2014/12/20 06:00
PHST- 2014/09/27 00:00 [received]
PHST- 2014/11/24 00:00 [revised]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2014/12/20 06:00 [entrez]
PHST- 2014/12/20 06:00 [pubmed]
PHST- 2015/08/11 06:00 [medline]
AID - S0304-3940(14)00958-6 [pii]
AID - 10.1016/j.neulet.2014.12.022 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Feb 5;587:6-10. doi: 10.1016/j.neulet.2014.12.022. Epub 2014 
      Dec 15.