PMID- 25525862 OWN - NLM STAT- MEDLINE DCOM- 20160622 LR - 20181202 IS - 1715-5320 (Electronic) IS - 1715-5312 (Linking) VI - 40 IP - 1 DP - 2015 Jan TI - Neurotrophins and cognitive functions in T1D compared with healthy controls: effects of a high-intensity exercise. PG - 20-7 LID - 10.1139/apnm-2014-0098 [doi] AB - Exercise is known to have beneficial effects on cognitive function. This effect is greatly favored by an exercise-induced increase in neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1), especially with high-intensity exercises (HIE). As a complication of type 1 diabetes (T1D), a cognitive decline may occur, mostly ascribed to hypoglycaemia and chronic hyperglycaemia. Therefore, the purpose of this study was to examine the effects of acute HIE on cognitive function and neurotrophins in T1D and matched controls. Ten trained T1D (8 males, 2 females) participants and their matched (by age, sex, fitness level) controls were evaluated on 2 occasions after familiarization: a maximal test to exhaustion and an HIE bout (10 intervals of 60 s at 90% of their maximal wattage followed by 60 s at 50 W). Cognitive tests and analyses of serum BDNF, IGF-1, and free insulin were performed before and after HIE and following 30 min of recovery. At baseline, cognitive performance was better in the controls compared with the T1D participants (p < 0.05). After exercise, no significant differences in cognitive performance were detected. BDNF levels were significantly higher and IGF-1 levels were significantly lower in T1D compared with the control group (p < 0.05) at all time points. Exercise increased BDNF and IGF-1 levels in a comparable percentage in both groups (p < 0.05). In conclusion, although resting levels of serum BDNF and IGF-1 were altered by T1D, comparable increasing effects on BDNF and IGF-1 in T1D and healthy participants were found. Therefore, regularly repeating acute HIE could be a promising strategy for brain health in T1D. FAU - Tonoli, Cajsa AU - Tonoli C AD - a Department of Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Pleinlaan 2 - B-1050 Brussels, Belgium. FAU - Heyman, Elsa AU - Heyman E FAU - Buyse, Luk AU - Buyse L FAU - Roelands, Bart AU - Roelands B FAU - Piacentini, Maria Francesca AU - Piacentini MF FAU - Bailey, Stephen AU - Bailey S FAU - Pattyn, Nathalie AU - Pattyn N FAU - Berthoin, Serge AU - Berthoin S FAU - Meeusen, Romain AU - Meeusen R LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Canada TA - Appl Physiol Nutr Metab JT - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JID - 101264333 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (IGF1 protein, human) RN - 0 (Insulin) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Bicycling MH - Biomarkers MH - Brain-Derived Neurotrophic Factor/*blood/metabolism MH - Cognition MH - Cognition Disorders/complications/*prevention & control MH - Diabetes Complications/*prevention & control MH - Diabetes Mellitus, Type 1/complications/metabolism/psychology/*therapy MH - Diabetic Neuropathies/complications/prevention & control MH - Female MH - Heart Rate MH - Humans MH - Insulin/blood MH - Insulin-Like Growth Factor I/*analysis/metabolism MH - Male MH - *Motor Activity MH - Neurogenesis MH - Oxygen Consumption MH - Physical Exertion MH - *Up-Regulation OTO - NOTNLM OT - brain-derived neurotrophic factor OT - cognition OT - diabetes OT - diabete OT - facteur de croissance insulinomimetique de type 1 OT - facteur neurotrophique derive du cerveau OT - free insulin OT - insulin-like growth factor-1 OT - insuline libre EDAT- 2014/12/20 06:00 MHDA- 2016/06/23 06:00 CRDT- 2014/12/20 06:00 PHST- 2014/12/20 06:00 [entrez] PHST- 2014/12/20 06:00 [pubmed] PHST- 2016/06/23 06:00 [medline] AID - 10.1139/apnm-2014-0098 [doi] PST - ppublish SO - Appl Physiol Nutr Metab. 2015 Jan;40(1):20-7. doi: 10.1139/apnm-2014-0098.