PMID- 25526973
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Dec 20
TI  - Endogenous assessment of chronic myocardial infarction with T(1rho)-mapping in 
      patients.
PG  - 104
LID - 10.1186/s12968-014-0104-y [doi]
LID - 104
AB  - BACKGROUND: Detection of cardiac fibrosis based on endogenous magnetic resonance 
      (MR) characteristics of the myocardium would yield a measurement that can provide 
      quantitative information, is independent of contrast agent concentration, renal 
      function and timing. In ex vivo myocardial infarction (MI) tissue, it has been 
      shown that a significantly higher T(1rho) is found in the MI region, and studies in 
      animal models of chronic MI showed the first in vivo evidence for the ability to 
      detect myocardial fibrosis with native T(1rho)-mapping. In this study we aimed to 
      translate and validate T(1rho)-mapping for endogenous detection of chronic MI in 
      patients. METHODS: We first performed a study in a porcine animal model of 
      chronic MI to validate the implementation of T(1rho)-mapping on a clinical 
      cardiovascular MR scanner and studied the correlation with histology. 
      Subsequently a clinical protocol was developed, to assess the feasibility of scar 
      tissue detection with native T(1rho)-mapping in patients (n = 21) with chronic MI, 
      and correlated with gold standard late gadolinium enhancement (LGE) CMR. Four 
      T1rho-weighted images were acquired using a spin-lock preparation pulse with 
      varying duration (0, 13, 27, 45 ms) and an amplitude of 750 Hz, and a T(1rho)-map 
      was calculated. The resulting T(1rho)-maps and LGE images were scored qualitatively 
      for the presence and extent of myocardial scarring using the 17-segment AHA 
      model. RESULTS: In the animal model (n = 9) a significantly higher T(1rho) 
      relaxation time was found in the infarct region (61 +/- 11 ms), compared to healthy 
      remote myocardium (36 +/- 4 ms) . In patients a higher T(1rho) relaxation time 
      (79 +/- 11 ms) was found in the infarct region than in remote myocardium (54 +/- 6 
      ms). Overlap in the scoring of scar tissue on LGE images and T(1rho)-maps was 74%. 
      CONCLUSION: We have shown the feasibility of native T(1rho)-mapping for detection 
      of infarct area in patients with a chronic myocardial infarction. In the near 
      future, improvements on the T(1rho)-mapping sequence could provide a higher 
      sensitivity and specificity. This endogenous method could be an alternative for 
      LGE imaging, and provide additional quantitative information on myocardial tissue 
      characteristics.
FAU - van Oorschot, Joep W M
AU  - van Oorschot JW
AD  - Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100 
      3582 CX, Utrecht, The Netherlands. j.w.m.oorschot@umcutrecht.nl.
FAU - El Aidi, Hamza
AU  - El Aidi H
FAU - Jansen of Lorkeers, Sanne J
AU  - Jansen of Lorkeers SJ
FAU - Gho, Johannes M I H
AU  - Gho JM
FAU - Froeling, Martijn
AU  - Froeling M
FAU - Visser, Fredy
AU  - Visser F
FAU - Chamuleau, Steven A J
AU  - Chamuleau SA
FAU - Doevendans, Pieter A
AU  - Doevendans PA
FAU - Luijten, Peter R
AU  - Luijten PR
FAU - Leiner, Tim
AU  - Leiner T
FAU - Zwanenburg, Jaco J M
AU  - Zwanenburg JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20141220
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Disease Models, Animal
MH  - Feasibility Studies
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/pathology/physiopathology
MH  - Myocardium/*pathology
MH  - Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Swine
MH  - Ventricular Function, Left
MH  - Young Adult
PMC - PMC4272542
EDAT- 2014/12/21 06:00
MHDA- 2015/08/25 06:00
PMCR- 2014/12/20
CRDT- 2014/12/21 06:00
PHST- 2014/06/06 00:00 [received]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2014/12/21 06:00 [entrez]
PHST- 2014/12/21 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
PHST- 2014/12/20 00:00 [pmc-release]
AID - S1097-6647(23)00101-1 [pii]
AID - 104 [pii]
AID - 10.1186/s12968-014-0104-y [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Dec 20;16(1):104. doi: 10.1186/s12968-014-0104-y.