PMID- 25527055 OWN - NLM STAT- MEDLINE DCOM- 20150818 LR - 20220311 IS - 1097-6779 (Electronic) IS - 0016-5107 (Linking) VI - 81 IP - 1 DP - 2015 Jan TI - EUS is superior for detection of pancreatic lesions compared with standard imaging in patients with multiple endocrine neoplasia type 1. PG - 159-167.e2 LID - S0016-5107(14)02257-3 [pii] LID - 10.1016/j.gie.2014.09.037 [doi] AB - BACKGROUND: In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (pNETs) are the leading MEN1-related cause of death. OBJECTIVE: To evaluate EUS and (11)C-5-hydroxytryptophan positron emission tomography ((11)C-5-HTP PET), compared with the recommended screening techniques in MEN1 patients for early detection of pNETs. DESIGN: Cross-sectional study. SETTING: Tertiary-care university medical center. PATIENTS: This study involved 41 patients with a proven MEN1 mutation or with one MEN1 manifestation and a mutation carrier as a first-degree family member, with recent screening by abdominal CT or magnetic resonance imaging (MRI) and somatostatin receptor scintigraphy (SRS). INTERVENTIONS: EUS by using a linear Pentax echoendoscope and Hitachi EUB-525 and (11)C-5-HTP PET. MAIN OUTCOME MEASUREMENTS: Patient-based and lesion-based positivity for pNET was calculated for all imaging techniques. The McNemar test was used to compare the yield of the 4 imaging techniques. RESULTS: In 35 of 41 patients, 107 pancreatic lesions were detected in total. EUS detected 101 pancreatic lesions in 34 patients, (11)C-5-HTP PET detected 35 lesions in 19 patients, and CT/MRI + SRS detected 32 lesions in 18 patients (P < .001). (11)C-5-HTP PET performed similarly to CT/MRI + SRS and better compared with SRS only (13 lesions in 12 patients), both at a patient-based and lesion-based level (P < .05). LIMITATIONS: Single-center study. CONCLUSION: EUS is superior to CT/MRI + SRS for pancreatic lesion detection in patients with MEN1. In this setting, (11)C-5-HTP PET is not useful. We recommend EUS as the first-choice pancreas imaging technique in patients with MEN1. ( CLINICAL TRIAL REGISTRATION NUMBER: NTR1668.). CI - Copyright (c) 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved. FAU - van Asselt, Sophie J AU - van Asselt SJ AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Brouwers, Adrienne H AU - Brouwers AH AD - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - van Dullemen, Hendrik M AU - van Dullemen HM AD - Department of Gastroenterology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - van der Jagt, Eric J AU - van der Jagt EJ AD - Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Bongaerts, Alfons H H AU - Bongaerts AH AD - Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Kema, Ido P AU - Kema IP AD - Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Koopmans, Klaas P AU - Koopmans KP AD - Department of Nuclear Medicine and Molecular Imaging, Martini Hospital Groningen, Groningen, The Netherlands. FAU - Valk, Gerlof D AU - Valk GD AD - Department of Endocrinology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Timmers, Henri J AU - Timmers HJ AD - Department of Medicine, Division of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. FAU - de Herder, Wouter W AU - de Herder WW AD - Department of Endocrinology, University Erasmus Medical Center, Rotterdam, The Netherlands. FAU - Feelders, Richard A AU - Feelders RA AD - Department of Endocrinology, University Erasmus Medical Center, Rotterdam, The Netherlands. FAU - Fockens, Paul AU - Fockens P AD - Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Sluiter, Wim J AU - Sluiter WJ AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - de Vries, Elisabeth G E AU - de Vries EG AD - Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Links, Thera P AU - Links TP AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. LA - eng SI - NTR/NTR1668 PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Gastrointest Endosc JT - Gastrointestinal endoscopy JID - 0010505 RN - 0 (Carbon Radioisotopes) RN - 0 (Radiopharmaceuticals) RN - C1LJO185Q9 (5-Hydroxytryptophan) SB - IM MH - 5-Hydroxytryptophan MH - Adolescent MH - Adult MH - Aged MH - Carbon Radioisotopes MH - Cross-Sectional Studies MH - Early Detection of Cancer MH - Endosonography MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/complications/*diagnosis MH - Neuroendocrine Tumors/*diagnosis/etiology MH - Pancreas/*diagnostic imaging MH - Pancreatic Neoplasms/*diagnosis/etiology MH - Positron-Emission Tomography MH - Prospective Studies MH - Radiopharmaceuticals MH - Sensitivity and Specificity MH - Tomography, X-Ray Computed MH - Young Adult EDAT- 2014/12/21 06:00 MHDA- 2015/08/19 06:00 CRDT- 2014/12/21 06:00 PHST- 2014/05/26 00:00 [received] PHST- 2014/09/10 00:00 [accepted] PHST- 2014/12/21 06:00 [entrez] PHST- 2014/12/21 06:00 [pubmed] PHST- 2015/08/19 06:00 [medline] AID - S0016-5107(14)02257-3 [pii] AID - 10.1016/j.gie.2014.09.037 [doi] PST - ppublish SO - Gastrointest Endosc. 2015 Jan;81(1):159-167.e2. doi: 10.1016/j.gie.2014.09.037.