PMID- 25528414
OWN - NLM
STAT- MEDLINE
DCOM- 20151104
LR  - 20150209
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 39
IP  - 1
DP  - 2015 Jan
TI  - Hepatic oxidative stress and inflammatory responses with cadmium exposure in male 
      mice.
PG  - 229-36
LID - S1382-6689(14)00299-3 [pii]
LID - 10.1016/j.etap.2014.11.029 [doi]
AB  - Cadmium (Cd), a non-essential heavy metal, is one of the major environmental 
      contaminants with grave toxicological consequences globally. In the present 
      study, the effects of Cd on hepatic oxidative stress and inflammatory responses 
      in mice were evaluated. Male adult mice were orally exposed to 3, 10 and 30mg/L 
      CdCl2 supplied in the drinking water for 7 and 21 days. Histopathological changes 
      and the alterations of the main parameters related to oxidative stress and 
      inflammatory responses in the liver were observed. Hepatic malondialdehyde (MDA) 
      contents increased significantly after treatment with 30mg/L CdCl2 for 21 days, 
      and the contents of glutathione (GSH) increased significantly in both 10 and 
      30mg/L CdCl2 treated groups. The hepatic activities of glutathione peroxidase 
      (GPX), catalase (CAT) and glutathione S-transferase (GST) increased significantly 
      after the treatment with 30mg/L CdCl2 for 21 days. In accordance with the enzyme 
      activities, the transcription status of hepatic superoxide dismutase 1 (Sod1), 
      superoxide dismutase 2 (Sod2), Cat, Gpx, Gstalpha1, glutathione synthetase (Gss), 
      glutathione reductase (Gr) and heme oxygenase 1 (Ho1) were also increased by high 
      dose (30mg/L) or long period (21 days) exposure. In addition, the serum levels of 
      tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL6) and interleukin 1beta (IL1beta) 
      increased significantly in the groups treated with 30mg/L CdCl2 for 21 days. And 
      the genes of TNFalpha, IL6, interleukin 1alpha (IL1alpha), inducible nitric oxide synthase 
      (iNOS) and interferon gamma (IFNgamma) were also increased in the liver of mice when 
      exposed to relative high dose of CdCl2 for 7 or 21 days. Taken together, the 
      results of this study suggested that the exposure to Cd had the potential to 
      induce immunotoxicity accompanied with oxidative stress in the liver of mice.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Liu, Ling
AU  - Liu L
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - Tao, Runhua
AU  - Tao R
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - Huang, Jie
AU  - Huang J
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - He, Xingzhi
AU  - He X
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - Qu, Lanya
AU  - Qu L
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - Jin, Yuanxiang
AU  - Jin Y
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China. Electronic address: jinyx@zjut.edu.cn.
FAU - Zhang, Songbin
AU  - Zhang S
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China.
FAU - Fu, Zhengwei
AU  - Fu Z
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, Hangzhou 310032, China. Electronic address: azwfu@zjut.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141210
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 00BH33GNGH (Cadmium)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Cadmium/*toxicity
MH  - Catalase/metabolism
MH  - Cytokines/blood/genetics
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Liver/*drug effects/metabolism/pathology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice, Inbred ICR
MH  - Oxidative Stress/drug effects
MH  - RNA, Messenger/metabolism
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Cadmium
OT  - Inflammatory responses
OT  - Liver
OT  - Mice
OT  - Oxidative stress
EDAT- 2014/12/22 06:00
MHDA- 2015/11/05 06:00
CRDT- 2014/12/22 06:00
PHST- 2014/07/18 00:00 [received]
PHST- 2014/11/13 00:00 [revised]
PHST- 2014/11/15 00:00 [accepted]
PHST- 2014/12/22 06:00 [entrez]
PHST- 2014/12/22 06:00 [pubmed]
PHST- 2015/11/05 06:00 [medline]
AID - S1382-6689(14)00299-3 [pii]
AID - 10.1016/j.etap.2014.11.029 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2015 Jan;39(1):229-36. doi: 
      10.1016/j.etap.2014.11.029. Epub 2014 Dec 10.