PMID- 25529393
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20220318
IS  - 1469-7610 (Electronic)
IS  - 0021-9630 (Linking)
VI  - 56
IP  - 1
DP  - 2015 Jan
TI  - Editorial: Process to progress? Investigative trials, mechanism and clinical 
      science.
PG  - 1-3
LID - 10.1111/jcpp.12377 [doi]
AB  - In 2002 Helena Kraemer and colleagues published an important article on the 
      analysis of clinical trials in mental health, which advocated a planned focus on 
      mechanisms to investigate the processes behind treatment effects. Kraemer et al. 
      considered not only new approaches to mediation analysis, but also a theoretical 
      approach to factors, both pre-treatment and during treatment, that might moderate 
      this mediation. Trials should not just be about whether a treatment 'worked', but 
      how it worked; with the results informing modification of the intervention for 
      the next trial by discarding aspects that were not effective and reinforcing 
      aspects that were - an iterative procedure towards greater effectiveness. Can we 
      enjoy similar ambitions for complex interventions within mental health? It is not 
      so long ago when the received wisdom within the clinical and much of the research 
      community was that it was simply impossible in practice to mount randomised 
      controlled trials relevant to the kind of psychosocial interventions we use in 
      child and adolescent mental health (CAMHS). How different the situation is now, 
      with burgeoning interest in a systematic evidence base for psychological 
      treatment and the possibilities for unexpected advances (as well as unexpected 
      harms). Nevertheless it is probably still fair to say that the systematic use of 
      process and mechanism study within trials in our field is the exception rather 
      than the rule. What are the possibilities and implications for our field?
CI  - (c) 2014 Association for Child and Adolescent Mental Health.
FAU - Green, Jonathan
AU  - Green J
LA  - eng
GR  - G0401546/MRC_/Medical Research Council/United Kingdom
GR  - MR/K005863/1/MRC_/Medical Research Council/United Kingdom
PT  - Editorial
PL  - England
TA  - J Child Psychol Psychiatry
JT  - Journal of child psychology and psychiatry, and allied disciplines
JID - 0375361
SB  - IM
MH  - Clinical Trials as Topic/*standards
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Outcome and Process Assessment, Health Care/*standards
OTO - NOTNLM
OT  - Investigative trials
OT  - causal effects
OT  - childhood mental health practice
OT  - complex interventions
OT  - developmental science
OT  - moderated mediation
OT  - treatment trial design
EDAT- 2014/12/23 06:00
MHDA- 2015/09/04 06:00
CRDT- 2014/12/23 06:00
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 10.1111/jcpp.12377 [doi]
PST - ppublish
SO  - J Child Psychol Psychiatry. 2015 Jan;56(1):1-3. doi: 10.1111/jcpp.12377.