PMID- 25529856
OWN - NLM
STAT- MEDLINE
DCOM- 20151224
LR  - 20181113
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 56
IP  - 1
DP  - 2015 May
TI  - Genetic variability testing of neurodevelopmental genes in schizophrenic 
      patients.
PG  - 205-11
LID - 10.1007/s12031-014-0482-5 [doi]
AB  - This study investigated the associations between single nucleotide polymorphisms 
      in the neurodevelopmental Disrupted In Schizophrenia 1 (DISC1 ), neuregulin 1 
      (NRG1), brain-derived neurotrophic factor (BDNF) and NOTCH4 genes and the 
      clinical symptoms and the occurrence of treatment-resistant schizophrenia in the 
      Slovenian population. We included 138 schizophrenia patients, divided into 
      treatment-responsive and treatment-resistant group and 94 healthy blood donors. 
      All subjects were genotyped for eight polymorphisms (DISC1 rs6675281, DISC1 
      rs821616, NRG1 rs3735781, NRG1 rs3735782, NRG1 rs10503929, NRG1 rs3924999, BDNF 
      rs6265, NOTCH rs367398) and investigated for associations with clinical 
      variables. NOTCH4 rs367398 AA/AG was significantly associated with worse Positive 
      and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) score. 
      NOTCH4 rs367398 was not statistically significantly associated with the 
      occurrence of treatment-resistant schizophrenia after the correction for multiple 
      testing. Our data indicate that NOTCH4 polymorphism can influence clinical 
      symptoms in Slovenian patients with schizophrenia.
FAU - Terzic, Tea
AU  - Terzic T
AD  - University Psychiatric Clinic Ljubljana, Studenec 48, 1260, Ljubljana, Slovenia.
FAU - Kastelic, Matej
AU  - Kastelic M
FAU - Dolzan, Vita
AU  - Dolzan V
FAU - Plesnicar, Blanka Kores
AU  - Plesnicar BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141223
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DISC1 protein, human)
RN  - 0 (NOTCH4 protein, human)
RN  - 0 (NRG1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuregulin-1)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Notch4)
RN  - 0 (Receptors, Notch)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*genetics
MH  - Neuregulin-1/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Proto-Oncogene Proteins/*genetics
MH  - Receptor, Notch4
MH  - Receptors, Notch/*genetics
MH  - Schizophrenia/*genetics
EDAT- 2014/12/23 06:00
MHDA- 2015/12/25 06:00
CRDT- 2014/12/23 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2014/12/14 00:00 [accepted]
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/12/25 06:00 [medline]
AID - 10.1007/s12031-014-0482-5 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 May;56(1):205-11. doi: 10.1007/s12031-014-0482-5. Epub 2014 
      Dec 23.