PMID- 25530445
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20181113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 22
IP  - 3
DP  - 2015 Mar
TI  - Obesity interacts with infectious mononucleosis in risk of multiple sclerosis.
PG  - 578-e38
LID - 10.1111/ene.12620 [doi]
AB  - BACKGROUND AND PURPOSE: The possible interaction between adolescent obesity and 
      past infectious mononucleosis (IM) was investigated with regard to multiple 
      sclerosis (MS) risk. METHODS: This report is based on two population-based 
      case-control studies, one with incident cases (1780 cases, 3885 controls) and one 
      with prevalent cases (4502 cases, 4039 controls). Subjects were categorized based 
      on adolescent body mass index (BMI) and past IM and compared with regard to 
      occurrence of MS by calculating odds ratios with 95% confidence intervals (CIs) 
      employing logistic regression. A potential interaction between adolescent BMI and 
      past IM was evaluated by calculating the attributable proportion due to 
      interaction. RESULTS: Regardless of human leukocyte antigen (HLA) status, a 
      substantial interaction was observed between adolescent obesity and past IM with 
      regard to MS risk. The interaction was most evident when IM after the age of 10 
      was considered (attributable proportion due to interaction 0.8, 95% CI 0.6-1.0 in 
      the incident study, and attributable proportion due to interaction 0.7, 95% CI 
      0.5-1.0 in the prevalent study). In the incident study, the odds ratio of MS was 
      14.7 (95% CI 5.9-36.6) amongst subjects with adolescent obesity and past IM after 
      the age of 10, compared with subjects with none of these exposures. The 
      corresponding odds ratio in the prevalent study was 13.2 (95% CI 5.2-33.6). 
      CONCLUSIONS: An obese state both impacts the cellular immune response to 
      infections and induces a state of chronic immune-mediated inflammation which may 
      contribute to explain our finding of an interaction between adolescent BMI and 
      past IM. Measures taken against adolescent obesity may thus be a preventive 
      strategy against MS.
CI  - (c) 2014 The Authors. European Journal of Neurology published by John Wiley & Sons 
      Ltd on behalf of European Academy of Neurology.
FAU - Hedstrom, A K
AU  - Hedstrom AK
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Lima Bomfim, I
AU  - Lima Bomfim I
FAU - Hillert, J
AU  - Hillert J
FAU - Olsson, T
AU  - Olsson T
FAU - Alfredsson, L
AU  - Alfredsson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141220
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Infectious Mononucleosis/*epidemiology
MH  - Inflammation/complications/*epidemiology/etiology
MH  - Male
MH  - Multiple Sclerosis/*epidemiology/etiology
MH  - Pediatric Obesity/complications/*epidemiology
MH  - Risk
MH  - Young Adult
PMC - PMC4365756
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - case-control study
OT  - demyelinating diseases
OT  - epidemiology
OT  - infectious mononucleosis
OT  - multiple sclerosis
OT  - obesity
OT  - risk factors
EDAT- 2014/12/23 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/03/19
CRDT- 2014/12/23 06:00
PHST- 2014/05/28 00:00 [received]
PHST- 2014/10/07 00:00 [accepted]
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/03/19 00:00 [pmc-release]
AID - 10.1111/ene.12620 [doi]
PST - ppublish
SO  - Eur J Neurol. 2015 Mar;22(3):578-e38. doi: 10.1111/ene.12620. Epub 2014 Dec 20.