PMID- 25531278
OWN - NLM
STAT- MEDLINE
DCOM- 20150826
LR  - 20240314
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 12
DP  - 2014
TI  - Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in inhabitants of Astana, the capital 
      city of Kazakhstan.
PG  - e115265
LID - 10.1371/journal.pone.0115265 [doi]
LID - e115265
AB  - BACKGROUND: Kazakhstan has been inhabited by different populations, such as the 
      Kazakh, Kyrgyz, Uzbek and others. Here we investigate allelic and haplotypic 
      polymorphisms of human leukocyte antigen (HLA) genes at DRB1, DQA1 and DQB1 loci 
      in the Kazakh ethnic group, and their genetic relationship between world 
      populations. METHODOLOGY/PRINCIPAL FINDINGS: A total of 157 unrelated Kazakh 
      ethnic individuals from Astana were genotyped using sequence based typing 
      (SBT-Method) for HLA-DRB1, -DQA1 and -DQB1 loci. Allele frequencies, 
      neighbor-joining method, and multidimensional scaling analysis have been obtained 
      for comparison with other world populations. Statistical analyses were performed 
      using Arlequin v3.11. Applying the software PAST v. 2.17 the resulting genetic 
      distance matrix was used for a multidimensional scaling analysis (MDS). 
      Respectively 37, 17 and 19 alleles were observed at HLA-DRB1, -DQA1 and -DQB1 
      loci. The most frequent alleles were HLA-DRB1*07:01 (13.1%), HLA-DQA1*03:01 
      (13.1%) and HLA-DQB1*03:01 (17.6%). In the observed group of Kazakhs 
      DRB1*07:01-DQA1*02:01-DQB1*02:01 (8.0%) was the most common three loci haplotype. 
      DRB1*10:01-DQB1*05:01 showed the strongest linkage disequilibrium. The Kazakh 
      population shows genetic kinship with the Kazakhs from China, Uyghurs, 
      Mongolians, Todzhinians, Tuvinians and as well as with other Siberians and 
      Asians. CONCLUSIONS/SIGNIFICANCE: The HLA-DRB1, -DQA1 and -DQB1 loci are highly 
      polymorphic in the Kazakh population, and this population has the closest 
      relationship with other Asian and Siberian populations.
FAU - Kuranov, Alexandr B
AU  - Kuranov AB
AD  - Medical University Clinic, Tubingen, Germany.
FAU - Vavilov, Mikhail N
AU  - Vavilov MN
AD  - Chelyabinsk Regional Blood Centre, Chelyabinsk, Russian Federation.
FAU - Abildinova, Gulshara Zh
AU  - Abildinova GZh
AD  - National Research Center for Maternal and Child Health, Astana, Kazakhstan.
FAU - Akilzhanova, Ainur R
AU  - Akilzhanova AR
AD  - National Center for Biotechnology, Astana, Kazakhstan.
FAU - Iskakova, Aisha N
AU  - Iskakova AN
AD  - National Center for Biotechnology, Astana, Kazakhstan.
FAU - Zholdybayeva, Elena V
AU  - Zholdybayeva EV
AD  - National Center for Biotechnology, Astana, Kazakhstan.
FAU - Boldyreva, Margarita N
AU  - Boldyreva MN
AD  - NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation.
FAU - Muller, Claudia A
AU  - Muller CA
AD  - Medical University Clinic, Tubingen, Germany.
FAU - Momynaliev, Kuvat T
AU  - Momynaliev KT
AD  - National Center for Biotechnology, Astana, Kazakhstan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141222
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Kazakhstan
MH  - Linkage Disequilibrium
MH  - *Polymorphism, Genetic
PMC - PMC4274022
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/12/23 06:00
MHDA- 2015/08/27 06:00
PMCR- 2014/12/22
CRDT- 2014/12/23 06:00
PHST- 2014/06/13 00:00 [received]
PHST- 2014/11/20 00:00 [accepted]
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/08/27 06:00 [medline]
PHST- 2014/12/22 00:00 [pmc-release]
AID - PONE-D-14-25298 [pii]
AID - 10.1371/journal.pone.0115265 [doi]
PST - epublish
SO  - PLoS One. 2014 Dec 22;9(12):e115265. doi: 10.1371/journal.pone.0115265. 
      eCollection 2014.