PMID- 25531464
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20161125
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Dec
TI  - Prevalence of high altitude pulmonary hypertension among the natives of Spiti 
      Valley--a high altitude region in Himachal Pradesh, India.
PG  - 504-10
LID - 10.1089/ham.2013.1112 [doi]
AB  - The study aimed to determine the prevalence of high altitude pulmonary 
      hypertension (HAPH) and its predisposing factors among natives of Spiti Valley. A 
      cross-sectional survey study was done on the permanent natives of Spiti Valley 
      residing at an altitude of 3000 m to 4200 m. Demographic characteristics, health 
      behavior, anthropometrics, and blood pressure were recorded. Investigations 
      included recording of 12 lead electrocardiogram (ECG), SaO2 with pulse oximeter, 
      spirometry and echocardiography study, and measurement of Hb levels using the 
      cynmethhemoglobin method. HAPH was diagnosed using criteria; tricuspid 
      regurgitation (TR) gradient of >/=46 mmHg. ECG evidence of RV overload on 12 lead 
      ECG was documented based on presence of 2 out of 3 criteria; R>S in V1, right 
      axis deviation or RV strain, T wave inversion in V1 and V2. Data of 1087 subjects 
      were analyzed who were free of cardiorespiratory diseases to determine the 
      prevalence of HAPH and its predisposing factors. HAPH was recorded in 3.23% (95% 
      C.I. of 0.9-8.1%) and ECG evidence of right ventricular (RV) overload was 1.5% in 
      the study population. Prevalence of HAPH was not different in men and women 2.63% 
      vs. 3.54% p<0.2. Age (Z statistics of 3.4 p<0.0006), hypoxemia (Z statistics of 
      2.9 p<0.002), and erythrocythemia (Z statistics of 4.7 p<0.003) were 
      independently associated with HAPH. Altitude of residence was not found to be 
      significantly associated with HAPH, although there was a trend of increasing 
      prevalence with increasing altitude. It can be concluded that HAPH is prevalent 
      in 3.23% of natives of Spiti Valley. Increasing age, erythrocythemia and 
      hypoxemia are independent predisposing factors.
FAU - Negi, Prakash Chand
AU  - Negi PC
AD  - Department of Cardiology, Indira Gandhi Medical College , Shimla, Himachal 
      Pradesh, India .
FAU - Marwaha, Rajeev
AU  - Marwaha R
FAU - Asotra, Sanjeev
AU  - Asotra S
FAU - Kandoria, Arvind
AU  - Kandoria A
FAU - Ganju, Neeraj
AU  - Ganju N
FAU - Sharma, Rajesh
AU  - Sharma R
FAU - Kumar, Ravi V
AU  - Kumar RV
FAU - Bhardwaj, Rajeev
AU  - Bhardwaj R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Adult
MH  - Altitude
MH  - Altitude Sickness/*epidemiology/*etiology
MH  - Anthropometry/methods
MH  - Blood Pressure
MH  - Causality
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Behavior
MH  - Humans
MH  - Hypertension, Pulmonary/*epidemiology/*etiology
MH  - Hypoxia/etiology
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Population Groups
MH  - Prevalence
OTO - NOTNLM
OT  - Himalayas India
OT  - high altitude
OT  - pulmonary hypertension
EDAT- 2014/12/23 06:00
MHDA- 2015/09/12 06:00
CRDT- 2014/12/23 06:00
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 10.1089/ham.2013.1112 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2014 Dec;15(4):504-10. doi: 10.1089/ham.2013.1112.