PMID- 25531957
OWN - NLM
STAT- MEDLINE
DCOM- 20150415
LR  - 20141223
IS  - 1551-7489 (Print)
IS  - 1551-7489 (Linking)
VI  - 10
IP  - 6
DP  - 2014 Nov-Dec
TI  - Effectiveness of opioid rotation in the control of cancer pain: the ROTODOL 
      study.
PG  - 395-403
LID - jom.2014.0236 [pii]
LID - 10.5055/jom.2014.0236 [doi]
AB  - OBJECTIVE: To assess the effectiveness of opioid rotation (OR) to manage cancer 
      pain. To describe the adverse events (AEs) associated with OR. SETTING: 
      Thirty-nine tertiary hospital services. PATIENTS: Sixty-seven oncological 
      patients with cancer-related pain treated at outpatient clinics. INTERVENTION: 
      Prospective multicenter study. Pain intensity was scored using a Numerical Rating 
      Scale (NRS) of 0-10. Average pain (AP) intensity in the last 24 hours, 
      breakthrough pain (BTP), and the number of episodes of BTP on the days before and 
      1 week after OR were assessed. The pre-OR and post-OR opioid were recorded. The 
      presence and intensity of any AEs occurring after OR were also recorded. RESULTS: 
      In the 67 patients evaluated, 75 ORs were recorded. In all cases, the main reason 
      for OR was poor pain control. Pain intensity decreased by >/=2 points after OR in 
      75.4 percent and 57.8 percent of cases for AP and BTP, respectively. If the 
      initial NRS score was >/=4, a decrease below <4 accounted for 50.9 percent and 32.3 
      percent of cases for AP and BTP, respectively. The number of episodes of BTP also 
      decreased significantly (p<0.001). A total of 107 AEs were reported, most of 
      which were mild in intensity, with gastrointestinal symptoms predominating. 
      CONCLUSIONS: Opioid rotation appears to be both safe and effective in the 
      management of basal and breakthrough cancer pain.
FAU - Gonzalez-Barboteo, Jesus
AU  - Gonzalez-Barboteo J
AD  - Palliative Care Service, Hospital Duran I Reynals, Institut Catala d'Oncologia, 
      L'Hospitalet de Llobregat, Barcelona, Spain; Chair of Palliative Care, Center for 
      Health and Social Studies, University of Vic., Barcelona, Spain; Palliative Care 
      Research Group, IDIBELL, Universitary Bellvitge Hospital, L'Hospitalet de 
      Llobregat, Barcelona, Spain.
FAU - Alentorn, Xavier Gomez-Batiste
AU  - Alentorn XG
AD  - Director of World Health Organization Collaborating Centre for Public Health 
      Palliative Care Programmes, Hospital Duran I Reynals, Institut Catala 
      d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Director of Chair of 
      Palliative Care, Center for Health and Social Studies, University of Vic., 
      Barcelona, Spain; Palliative Care Research Group, IDIBELL, Universitary Bellvitge 
      Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Manuel, Felipe A Calvo
AU  - Manuel FA
AD  - Chief of Oncology Department, Hospital General Universitario Gregorio Maranon, 
      Madrid, Spain; Professor of Complutense, University of Madrid, Madrid, Spain.
FAU - Candel, Vicente Alberola
AU  - Candel VA
AD  - Chief of Medical Oncology Service, Hospital Arnau de Vilanova, Valencia, Spain; 
      Professor of Medical Oncology, Medical Oncology Service, Hospital Arnau de 
      Vilanova, Universitat de Valencia, Valencia, Spain.
FAU - Eito, M Amalia Palacios
AU  - Eito MA
AD  - Chief of Radiotherapy Oncology Service, Hospital Universitario Provincial Reina 
      Sofia, Cordoba, Spain.
FAU - Sanchez-Magro, Isabel
AU  - Sanchez-Magro I
AD  - Medical Director of Medical Department, Grunenthal Iberia, Madrid, Spain.
FAU - Alvarez, Marta Neira
AU  - Alvarez MN
AD  - Medical Department, Grunenthal Iberia, Madrid, Spain.
FAU - Martin, F Javier Perez
AU  - Martin FJ
AD  - Clinical Research Unit, Hospital Duran I Reynals, Institut Catala d'Oncologia, 
      L'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Porta-Sales, Josep
AU  - Porta-Sales J
AD  - Chief of Palliative Care Service Research Unit, Hospital Duran I Reynals, 
      Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; 
      Palliative Care Research Group, IDIBELL, Universitary Bellvitge Hospital, 
      L'Hospitalet de Llobregat, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Opioid Manag
JT  - Journal of opioid management
JID - 101234523
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analgesics, Opioid/*administration & dosage/adverse effects
MH  - Breakthrough Pain/diagnosis/*drug therapy/etiology
MH  - Chronic Pain/diagnosis/*drug therapy/etiology
MH  - Drug Administration Schedule
MH  - *Drug Substitution
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Spain
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/12/23 06:00
MHDA- 2015/04/16 06:00
CRDT- 2014/12/23 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/09/30 00:00 [revised]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/12/23 06:00 [entrez]
PHST- 2014/12/23 06:00 [pubmed]
PHST- 2015/04/16 06:00 [medline]
AID - jom.2014.0236 [pii]
AID - 10.5055/jom.2014.0236 [doi]
PST - ppublish
SO  - J Opioid Manag. 2014 Nov-Dec;10(6):395-403. doi: 10.5055/jom.2014.0236.