PMID- 25533130
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20150124
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 135
IP  - 2
DP  - 2015 Feb
TI  - Annexin A2 autoantibodies in thrombosis and autoimmune diseases.
PG  - 226-30
LID - S0049-3848(14)00670-7 [pii]
LID - 10.1016/j.thromres.2014.11.034 [doi]
AB  - Antiphospholipid syndrome (APS) is an autoimmune disease characterized by 
      arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or 
      fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid 
      (PL) antibodies (Ab), typically associated with anti-beta2 glycoprotein I 
      (beta2GPI)-Ab. Recent studies suggest that anti-beta2GPI Ab activity involves a protein 
      complex including beta2GPI and annexin A2 (ANXA2). Anti-ANXA2 Ab recognizes this 
      complex, and these Ab can effectively promote thrombosis by inhibiting plasmin 
      generation, and by activating endothelial cells. Therefore, anti-ANXA2 Ab 
      represent a new biomarker, which can be detected in up to 25% of APS patients. 
      Moreover, anti-ANXA2 Ab have been detected, in thrombotic associated diseases 
      including pre-eclampsia, in other autoimmune diseases, and in cancer.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Canas, Felipe
AU  - Canas F
AD  - INSERM ESPRI, ERI29/EA2216 Immunology, Pathology and Immunotherapy, Labex IGO, 
      SFR ScinBios, Reseau canaux ioniques et Reseau epigenetique du Canceropole Grand 
      Ouest, European University of Brittany, Brest, France; Center for Autoimmune 
      Diseases Research (CREA) School of Medicine and Health Sciences Universidad del 
      Rosario, Bogota, Colombia.
FAU - Simonin, Laurent
AU  - Simonin L
AD  - INSERM ESPRI, ERI29/EA2216 Immunology, Pathology and Immunotherapy, Labex IGO, 
      SFR ScinBios, Reseau canaux ioniques et Reseau epigenetique du Canceropole Grand 
      Ouest, European University of Brittany, Brest, France; Laboratory of Immunology 
      and Immunotherapy, Brest University Medical School Hospital, Morvan, Brest, 
      France; Department of Internal Medicine, Brest University Medical School 
      Hospital, Cavale Blanche, Brest, France.
FAU - Couturaud, Francis
AU  - Couturaud F
AD  - Department of Internal Medicine, Brest University Medical School Hospital, Cavale 
      Blanche, Brest, France.
FAU - Renaudineau, Yves
AU  - Renaudineau Y
AD  - INSERM ESPRI, ERI29/EA2216 Immunology, Pathology and Immunotherapy, Labex IGO, 
      SFR ScinBios, Reseau canaux ioniques et Reseau epigenetique du Canceropole Grand 
      Ouest, European University of Brittany, Brest, France; Laboratory of Immunology 
      and Immunotherapy, Brest University Medical School Hospital, Morvan, Brest, 
      France. Electronic address: yves.renaudineau@univ-brest.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141213
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Annexin A2)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Annexin A2/*metabolism
MH  - Antiphospholipid Syndrome/*immunology
MH  - Autoantibodies/*immunology
MH  - Autoimmune Diseases/*immunology
MH  - Humans
MH  - Thrombosis/*immunology
OTO - NOTNLM
OT  - Annexin A2
OT  - Antiphospholipid syndrome
OT  - Autoantibodies
OT  - Lupus
EDAT- 2014/12/24 06:00
MHDA- 2015/10/09 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2014/10/29 00:00 [revised]
PHST- 2014/11/01 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - S0049-3848(14)00670-7 [pii]
AID - 10.1016/j.thromres.2014.11.034 [doi]
PST - ppublish
SO  - Thromb Res. 2015 Feb;135(2):226-30. doi: 10.1016/j.thromres.2014.11.034. Epub 
      2014 Dec 13.