PMID- 25533289
OWN - NLM
STAT- MEDLINE
DCOM- 20160217
LR  - 20181113
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 93
IP  - 5
DP  - 2015 May-Jun
TI  - A microRNA expression atlas of mouse dendritic cell development.
PG  - 480-5
LID - 10.1038/icb.2014.109 [doi]
AB  - Dendritic cells (DCs) are sentinel cells of the immune system and are essential 
      for inducing a proper immune response. The mechanisms driving the development of 
      DCs are not fully understood. Although the roles of cytokines and transcription 
      factors have been a major focus, there is now substantial interest in the role of 
      microRNAs (miRNAs). miRNAs are small RNAs that regulate gene expression by 
      targeting messenger RNAs for translational repression and ultimately degradation. 
      By means of deep sequencing, we have assembled a comprehensive and quantitative 
      resource of miRNA expression during DC development. We show that mature DCs and 
      their hematopoietic progenitors can be distinguished based on miRNA expression 
      profiles. On the other hand, we show that functionally distinct conventional and 
      plasmacytoid DC subsets are indistinguishable based on miRNA profile. In 
      addition, we identify differences between ex vivo purified conventional DCs and 
      their in vitro Flt3L-generated counterparts. This miRNA expression atlas will 
      provide a valuable resource for the study of miRNAs in DC development and 
      function.
FAU - Johanson, Timothy M
AU  - Johanson TM
AD  - 1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 
      Australia [2] Department of Medical Biology, University of Melbourne, Parkville, 
      Victoria, Australia [3] Immunology and Diabetes, St Vincent's Institute of 
      Medical Research, Fitzroy, Victoria, Australia.
FAU - Cmero, Marek
AU  - Cmero M
AD  - Immunology and Diabetes, St Vincent's Institute of Medical Research, Fitzroy, 
      Victoria, Australia.
FAU - Wettenhall, James
AU  - Wettenhall J
AD  - Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 
      Australia.
FAU - Lew, Andrew M
AU  - Lew AM
AD  - 1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 
      Australia [2] Department of Medical Biology, University of Melbourne, Parkville, 
      Victoria, Australia.
FAU - Zhan, Yifan
AU  - Zhan Y
AD  - 1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 
      Australia [2] Department of Medical Biology, University of Melbourne, Parkville, 
      Victoria, Australia.
FAU - Chong, Mark M W
AU  - Chong MM
AD  - 1] Immunology and Diabetes, St Vincent's Institute of Medical Research, Fitzroy, 
      Victoria, Australia [2] Department of Medicine (St Vincent's), University of 
      Melbourne, Fitzroy, Victoria, Australia.
LA  - eng
SI  - GEO/GSE57442
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141223
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (MicroRNAs)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-3)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cells, Cultured
MH  - Dendritic Cells/*physiology
MH  - Gene Expression Profiling
MH  - Hematopoiesis/genetics
MH  - Hematopoietic Stem Cells/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/genetics/*metabolism
MH  - Multigene Family
MH  - Vascular Endothelial Growth Factor Receptor-3/metabolism
EDAT- 2014/12/24 06:00
MHDA- 2016/02/18 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/10/02 00:00 [received]
PHST- 2014/11/25 00:00 [revised]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - icb2014109 [pii]
AID - 10.1038/icb.2014.109 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2015 May-Jun;93(5):480-5. doi: 10.1038/icb.2014.109. Epub 2014 
      Dec 23.