PMID- 25534375
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20220409
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 33
IP  - 9
DP  - 2015 Mar 20
TI  - Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or 
      without carboplatin in human epidermal growth factor receptor 2-positive and 
      triple-negative primary breast cancers.
PG  - 983-91
LID - 10.1200/JCO.2014.58.1967 [doi]
AB  - PURPOSE: Modulation of immunologic interactions in cancer tissue is a promising 
      therapeutic strategy. To investigate the immunogenicity of human epidermal growth 
      factor receptor 2 (HER2) -positive and triple-negative (TN) breast cancers (BCs), 
      we evaluated tumor-infiltrating lymphocytes (TILs) and immunologically relevant 
      genes in the neoadjuvant GeparSixto trial. PATIENTS AND METHODS: GeparSixto 
      investigated the effect of adding carboplatin (Cb) to an 
      anthracycline-plus-taxane combination (PM) on pathologic complete response (pCR). 
      A total of 580 tumors were evaluated before random assignment for stromal TILs 
      and lymphocyte-predominant BC (LPBC). mRNA expression of immune-activating 
      (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive 
      factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors. RESULTS: 
      Increased levels of stromal TILs predicted pCR in univariable (P < .001) and 
      multivariable analyses (P < .001). pCR rate was 59.9% in LPBC and 33.8% for 
      non-LPBC (P < .001). pCR rates >/= 75% were observed in patients with LPBC tumors 
      treated with PMCb, with a significant test for interaction with therapy in the 
      complete (P = .002) and HER2-positive (P = .006), but not the TNBC, cohorts. 
      Hierarchic clustering of mRNA markers revealed three immune subtypes with 
      different pCR rates (P < .001). All 12 immune mRNA markers were predictive for 
      increased pCR. The highest odds ratios (ORs) were observed for PD-L1 (OR, 1.57; 
      95% CI, 1.34 to 1.86; P < .001) and CCL5 (OR, 1.41; 95% CI, 1.23 to 1.62; P < 
      .001). CONCLUSION: Immunologic factors were highly significant predictors of 
      therapy response in the GeparSixto trial, particularly in patients treated with 
      Cb. After further standardization, they could be included in histopathologic 
      assessment of BC.
CI  - (c) 2014 by American Society of Clinical Oncology.
FAU - Denkert, Carsten
AU  - Denkert C
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France. 
      carsten.denkert@charite.de.
FAU - von Minckwitz, Gunter
AU  - von Minckwitz G
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Brase, Jan C
AU  - Brase JC
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Sinn, Bruno V
AU  - Sinn BV
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Gade, Stephan
AU  - Gade S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Kronenwett, Ralf
AU  - Kronenwett R
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Pfitzner, Berit M
AU  - Pfitzner BM
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Salat, Christoph
AU  - Salat C
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Loi, Sherene
AU  - Loi S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Schmitt, Wolfgang D
AU  - Schmitt WD
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Schem, Christian
AU  - Schem C
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Fisch, Karin
AU  - Fisch K
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Darb-Esfahani, Silvia
AU  - Darb-Esfahani S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Mehta, Keyur
AU  - Mehta K
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Sotiriou, Christos
AU  - Sotiriou C
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Wienert, Stephan
AU  - Wienert S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Klare, Peter
AU  - Klare P
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Andre, Fabrice
AU  - Andre F
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Klauschen, Frederick
AU  - Klauschen F
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Blohmer, Jens-Uwe
AU  - Blohmer JU
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Krappmann, Kristin
AU  - Krappmann K
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Schmidt, Marcus
AU  - Schmidt M
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Tesch, Hans
AU  - Tesch H
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Kummel, Sherko
AU  - Kummel S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Sinn, Peter
AU  - Sinn P
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Jackisch, Christian
AU  - Jackisch C
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Dietel, Manfred
AU  - Dietel M
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Reimer, Toralf
AU  - Reimer T
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Untch, Michael
AU  - Untch M
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
FAU - Loibl, Sibylle
AU  - Loibl S
AD  - Carsten Denkert, Bruno V. Sinn, Berit M. Pfitzner, Wolfgang D. Schmitt, Silvia 
      Darb-Esfahan, Stephan Wienert, Frederick Klauschen, and Manfred Dietel, Charite 
      Universitatsmedizin Berlin; Carsten Denkert, German Cancer Consortium (DKTK); 
      Peter Klare, Praxisklinik and Breast Center; Jens-Uwe Blohmer, St Gertrauden 
      Krankenhaus and Charite Universitatsmedizin; Micheal Untch, Helios Klinikum 
      Berlin-Buch, Berlin; Gunter von Minckwitz, Stephan Gade, Keyur Mehta, and Sibylle 
      Loibl, German Breast Group, Neu-Isenburg; Gunter von Minckwitz, Women's Hospital, 
      University of Frankfurt; Hans Tesch, Bethanien Hospital, Frankfurt; Jan C. Brase, 
      Ralf Kronenwett, Karin Fisch, and Kristin Krappmann, Sividon Diagnostics, 
      Cologne; Ralf Kronenwett, Heinrich-Heine University Dusseldorf, Dusseldorf; 
      Christian Schem, Christian-Albrechts Universitat zu Kiel, Kiel; Christoph Salat, 
      Onkologische Schwerpunktpraxis, Munich; Marcus Schmidt, Johannes-Gutenberg 
      Universitat Mainz, Mainz; Sherko Kummel, Kliniken Essen-Mitte, Essen; Peter Sinn, 
      University of Heidelberg, Heidelberg; Christian Jakisch and Sibylle Loibl, Sana 
      Klinikum Offenbach, Offenbach; Toralf Reimer, Klinikum Sudstadt, Rostock, 
      Germany; Sherene Loi, Peter MacCallum Cancer Center, Melbourne, Victoria, 
      Australia; Sherene Loi and Christos Sotiriou, Institute Jules Bordet, Brussels, 
      Belgium; and Fabrice Andre, Institute Gustave Roussy, Villejuif, France.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20141222
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
RN  - BG3F62OND5 (Carboplatin)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
CIN - J Clin Oncol. 2015 Mar 20;33(9):969-71. PMID: 25559817
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/therapeutic use
MH  - Biomarkers, Tumor/metabolism
MH  - Carboplatin/*administration & dosage
MH  - Chemotherapy, Adjuvant/*methods
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymphocytes, Tumor-Infiltrating/*metabolism
MH  - Middle Aged
MH  - Neoadjuvant Therapy/*methods
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic
MH  - Receptor, ErbB-2/*metabolism
MH  - Triple Negative Breast Neoplasms/*drug therapy/metabolism
EDAT- 2014/12/24 06:00
MHDA- 2015/05/29 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - JCO.2014.58.1967 [pii]
AID - 10.1200/JCO.2014.58.1967 [doi]
PST - ppublish
SO  - J Clin Oncol. 2015 Mar 20;33(9):983-91. doi: 10.1200/JCO.2014.58.1967. Epub 2014 
      Dec 22.