PMID- 25534498
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20150316
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 4
DP  - 2015 Apr
TI  - Microstructural changes in the retina related to prematurity.
PG  - 797-802
LID - S0002-9394(14)00821-6 [pii]
LID - 10.1016/j.ajo.2014.12.015 [doi]
AB  - PURPOSE: To assess retinal morphology changes in patients born at different 
      stages of prematurity, accounting for the presence or absence of retinopathy of 
      prematurity (ROP) and comorbidity, using spectral-domain optical coherence 
      tomography (SD OCT). DESIGN: Retrospective cohort study. METHODS: Preterm and 
      term infants underwent an ophthalmologic assessment (best-corrected visual 
      acuity, stereoacuity, cycloplegic refraction and funduscopy). Retinal layers were 
      imaged, segmented, and measured by SD-OCT. In total 114 full term controls and 60 
      preterm children, classified as late preterm (32-36 weeks gestational age), early 
      preterm (<32 weeks of gestational age) without ROP, and early preterm with 
      previously treated ROP, were included in the study. RESULTS: No retinal structure 
      differences were observed in preterm infants with no treated ROP compared to term 
      infants. Early preterm infants with previous treated ROP had decreased retinal 
      nerve fiber layer (RNFL) thickness in the superior and nasal quadrants, increased 
      RNFL in the temporal quadrant, and a thinner ganglion cell and inner plexiform 
      layer complex (GCL-IPL). Low birthweight percentile was associated with increased 
      foveal thickness and ganglion cell damage (RNFL and GCL-IPL) independent of 
      gestational age. Among all the coexisting events, inflammation and hypoxia were 
      correlated with more severe detrimental effects. CONCLUSIONS: In the absence of 
      treated ROP, prematurity was not associated with disturbed retinal structure. 
      Severe ROP and low birthweight were related to neuronal and axonal damage in the 
      inner retinal layers. Detailed comorbidity should be reviewed when evaluating 
      preterm infants.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Pueyo, Victoria
AU  - Pueyo V
AD  - Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain; 
      Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain. Electronic address: 
      vpueyo@unizar.es.
FAU - Gonzalez, Inmaculada
AU  - Gonzalez I
AD  - Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain; 
      Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain.
FAU - Altemir, Irene
AU  - Altemir I
AD  - Hospital Universitario Miguel Servet, Zaragoza, Spain; Instituto Aragones de 
      Ciencias de la Salud, Zaragoza, Spain.
FAU - Perez, Teresa
AU  - Perez T
AD  - Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain; 
      Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain.
FAU - Gomez, Galadriel
AU  - Gomez G
AD  - Hospital Universitario Miguel Servet, Zaragoza, Spain; Instituto Aragones de 
      Ciencias de la Salud, Zaragoza, Spain.
FAU - Prieto, Esther
AU  - Prieto E
AD  - Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain; 
      Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain.
FAU - Oros, Daniel
AU  - Oros D
AD  - Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain; Obstetrics 
      Department, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141220
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Birth Weight
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Premature
MH  - Laser Coagulation
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Refraction, Ocular/physiology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinopathy of Prematurity/*diagnosis/surgery
MH  - Retrospective Studies
MH  - Term Birth
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2014/12/24 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/10/24 00:00 [received]
PHST- 2014/12/09 00:00 [revised]
PHST- 2014/12/11 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0002-9394(14)00821-6 [pii]
AID - 10.1016/j.ajo.2014.12.015 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Apr;159(4):797-802. doi: 10.1016/j.ajo.2014.12.015. Epub 
      2014 Dec 20.