PMID- 25535128
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20220409
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 18
IP  - 23
DP  - 2014
TI  - Relationship between blood glucose fluctuation and macrovascular endothelial 
      dysfunction in type 2 diabetic patients with coronary heart disease.
PG  - 3593-600
LID - 8158 [pii]
AB  - OBJECTIVE: To evaluate the relationship between blood glucose fluctuation and 
      macrovascular dysfunction. PATIENTS AND METHODS: Eighty-eight type 2 diabetes 
      mellitus (T2DM) patients with or without coronary heart disease (CHD) and 30 
      healthy control subjects were recruited. Glycosylated hemoglobin A1c (HbA1c), 
      fasting insulin (FIns), and C-reaction protein (CRP) and some other general 
      clinical variables were measured. A 72-hour continuous glucose monitoring (CGM) 
      and brachial artery endothelium-dependent flow-mediated dilation (FMD) assessment 
      were performed. The glucose excursion, MAGE (mean amplitude of glycemic 
      excursions), LAGE (largest amplitude of glycemic excursions), MPPGE (mean 
      postprandial glycemic excursions), MODD (absolute means of daily differences), 
      and IAUC70 (incremental area under the curve below 70 mg/dl) during the CGM were 
      analyzed. Correlations between the various variables were analyzed. RESULTS: 
      Enhanced blood glucose fluctuation was observed in T2DM patients with CHD as 
      compared to other participants. And blood glucose fluctuation was correlated with 
      FMD, CRP and HOMA-IR. CONCLUSIONS: Blood glucose fluctuation is an important 
      factor that affects inflammatory response and possibly induces CHD in T2DM 
      patients.
FAU - Zhang, X-G
AU  - Zhang XG
AD  - Department of Endocrinology, General Hospital of Beijing Military Area, Beijing, 
      PR China. xiaofenglv7966@163.com.
FAU - Zhang, Y-Q
AU  - Zhang YQ
FAU - Zhao, D-K
AU  - Zhao DK
FAU - Wu, J-X
AU  - Wu JX
FAU - Zhao, J
AU  - Zhao J
FAU - Jiao, X-M
AU  - Jiao XM
FAU - Chen, B
AU  - Chen B
FAU - Lv, X-F
AU  - Lv XF
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Coronary Disease/*blood/*diagnosis/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis/epidemiology
MH  - Endothelium, Vascular/*pathology
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
EDAT- 2014/12/24 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - 8158 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2014;18(23):3593-600.